High dose corticosteroid pulses in treatment-resistant depression : a randomized double-blind placebo-controlled pilot study - Treating Unresponsive Depression – Overcoming Refractoriness

niversity Hospitals Bristol NHS Foundation Trust0 个研究点目标入组 40 人开始时间: 2008年3月25日最近更新: 2019年12月10日

试验速览

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•Patients will be aged 21- 75, have DSM-IV major depression and a Montgomery Asberg Depression Score (MADRS) >20. They will not be responding to their current treatment and have failed at least two treatments in the current episode. Patients will be able to give written, informed consent
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range

•History of psychotic symptoms, of reported significant memory impairment, of significant head trauma, of antisocial personality disorder, of alcohol or drug dependence, of hypertension, of duodenal or gastric ulcers, of diabetes, of glaucoma or of cataracts. Current suicidal intent, pregnancy or infection. Past neurosurgery for affective disorders, resistance to ECT, history of mania, resistance to TMS or to Magnetic Stimulation Therapy. Antidepressant medication change within the previous 6 weeks. Patient reports that they have not had chickenpox. Significant abnormalities in baseline physical examination or routine blood tests (FBC, U&E, LFT, TFT, ESR). Abnormal Fasting Blood Glucose. Weight <120Kg, BMI <40.

发起方

niversity Hospitals Bristol NHS Foundation Trust