Renal Biomarkers to Predict Recovery Following Venoarterial Extracorporeal Membrane Oxygenation
Terminated
- Conditions
- Acute Kidney Injury
- Registration Number
- NCT02978378
- Lead Sponsor
- Milton S. Hershey Medical Center
- Brief Summary
The investigators objective is to assess the utility of renal biomarkers in predicting renal recovery following institution of Venoarterial Extracorporeal Membrane Oxygenation (VA-ECMO). Tissue biomarkers of renal injury may provide a real-time indication of renal function and the likelihood of renal recovery in patients having cardiogenic shock and requiring VA-ECMO. In these patients, traditional markers of kidney function (urine output and serum Creatinine level) do not accurately represent renal function.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 2
Inclusion Criteria
- age more than 18 years
- refractory or advanced cardiogenic shock prior to institution of VA-ECMO
Exclusion Criteria
- History of chronic kidney disease prior to cardiogenic shock, as defined by estimated glomerular filtration rate (GFR) less than 60 mL per min
- Cognitive impairment
- Pregnant women
- patient or surrogate is not fluent in English
- Long-term immunosuppression
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method renal biomarker levels through VA-ECMO decannulation, an average of 3 weeks need for continuous renal replacement therapy at hospital discharge (Yes/No) measured at hospital discharge, an average of 2-3 months following initial hospital admission The need for continuous renal replacement therapy at hospital discharge will be assessed using hospital medical records
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Milton S. Hershey Medical Center
🇺🇸Hershey, Pennsylvania, United States