NCT07274345尚未招募不适用
Prevalence and Risk Factors Associated With Resistance to Antiviral Therapy in Egyptian Patients With Chronic Hepatitis B Virus Infection
Amira Mohamed Zidan0 个研究点目标入组 2,000 人开始时间: 2025年12月1日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 2,000
- 主要终点
- Proportion of Patients Exhibiting Antiviral Resistance Detection of HBV Antiviral Resistance Mutations
研究概览
简要总结
This study aims to determine the prevalence of antiviral drug resistance among Egyptian patients with chronic hepatitis B virus (HBV) infection and to identify the associated demographic, clinical, and virological risk factors. Understanding patterns of resistance will help improve treatment selection and optimize long-term management strategies for HBV patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •This study will include all chronic HBV-infected patients, either cirrhotic or not, receiving TDF 300 mg, ETV 0.5 or 1mg, or lamivudine 100 mg, irrespective of HBeAg status. The HBV chronicity is defined by persistence of HbsAg positivity for more than 6 months.
排除标准
- •Patients younger than 18 years old.
结局指标
主要结局
Proportion of Patients Exhibiting Antiviral Resistance Detection of HBV Antiviral Resistance Mutations
时间窗: 6 months
次要结局
未报告次要终点
研究者
Amira Mohamed Zidan
Resident Doctor Tropical Medicine and Gastroenterology
Sohag University
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