NCT02860793已完成不适用
Role of PTK-7 in Acute Myeloid Leukemias: Impact of PTK7 Serum Marker and ex Vivo Studies to Decipher the Role of PTK7
Institut Paoli-Calmettes2 个研究点 分布在 1 个国家目标入组 10 人开始时间: 2014年1月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 10
- 试验地点
- 2
- 主要终点
- Soluble PTK7 measurement in the serum
研究概览
简要总结
The pseudo tyrosine kinase receptor 7 (PTK7) is an orphan tyrosine kinase receptor assigned to the planar cell polarity pathway. PTK7 is expressed in normal myeloid progenitors and CD34(+) CD38(-) bone marrow cells in humans. It is also expressed in acute myeloid leukemia (AML) and is mostly assigned to granulocytic lineage differentiation. In AML, PTK7 seems to convey promigratory and antiapoptotic signals into the cell and represents an independent prognosis factor of survival in patients treated with induction chemotherapy. This study aims at:
- evaluating the impact of PTK7 expression on primary AML cells ex vivo
- evaluating the diagnostic and prognostic value of a soluble form of PTK7
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age> 18 years
- •AML at diagnosis, not previously treated
- •Treatment by induction chemotherapy
- •Signed informed consent
- •Affiliation to the French social security system
排除标准
- •pregnant woman(or of childbearing potential) or breastfeeding woman
- •emergency
- •patients deprived of liberty or placed under the authority of a tutor
结局指标
主要结局
Soluble PTK7 measurement in the serum
时间窗: 12 years
Evaluation PTK7+ and PTK7- AML cells hematopoietic homing abilities in xenografted mice by in vivo bioluminescence imaging
时间窗: 1 day
次要结局
未报告次要终点
研究者
研究点 (2)
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