Treatment of Bacterial Conjunctivitis With SHP640 Compared to PVP-Iodine and Placebo

Phase 3

Completed

Conditions: Bacterial Conjunctivitis

Interventions: Drug: PVP-I 0.6%
Drug: Placebo
Drug: SHP640

Registration Number: NCT03004924

Lead Sponsor: Shire

Brief Summary: The purpose of this study is to determine if an investigational treatment is effective compared with placebo and PVP-Iodine in the treatment of adults and children with bacterial conjunctivitis.

Detailed Description: Not available

Recruitment & Eligibility

Status: COMPLETED

Sex: All

Target Recruitment: 753

Inclusion Criteria

An understanding, ability, and willingness to fully comply with study procedures and restrictions (by the parent(s), guardian, or legally authorized representative, if applicable).
Ability to voluntarily provide written, signed, and dated (personally or via a parent(s), guardian, or legally authorized representative(s) informed consent (and assent, if applicable) to participate in the study.
Participants of any age at Visit 1 (Note: participants less than (<) 3 months of age at Visit 1 must have been full-term, that is (ie,) greater than or equal to (>=) 37 weeks gestational age at birth).
Have a negative AdenoPlus® test in both eyes within 24 hours of Visit 1 or at Visit 1.
Have a clinical diagnosis of suspected bacterial conjunctivitis in at least 1 eye confirmed by the presence of the following minimal clinical signs and symptoms in that same eye:
1. Report presence of signs and/or symptoms of bacterial conjunctivitis for less than or equal to (<=) 4 days prior to Visit 1
2. Bulbar conjunctival injection: a grade of >= 1 on 0-4 scale of Bulbar Conjunctival Injection Scale
3. Ocular conjunctival discharge: a grade of >= 1 (mild) on a 0-3 scale of Ocular Conjunctival Discharge Scale
Be willing to discontinue contact lens wear for the duration of the study.
Have a Best Corrected Visual Acuity (BCVA) of 0.60 logMAR or better in each eye as measured using an Early Treatment Diabetic Retinopathy Study (ETDRS) chart. BCVA will be assessed by an age appropriate method in accordance with the AAP Policy Statement for Visual System Assessment in Infants, Children, and Young Adults by Pediatricians (Donahue and Baker, 2016; American Academy of Pediatrics, 2016). The policy statement recommends formal vision screening can begin at 3 years of age. VA measurements for children under the age of 3 will be done at the discretion of the investigator. If not done, child should be able to fixate on and follow a moving object, except participants < 2 months of age who have not yet developed this ability. Participants < 2 months will be enrolled at the discretion of investigator.
Male, or non-pregnant, non-lactating female who agrees to comply with any applicable contraceptive requirements of the protocol or females of non-childbearing potential.

Exclusion Criteria

Current or recurrent disease that could affect the action, absorption, or disposition of the investigational product, or clinical or laboratory assessments, per investigator's discretion.
Current or relevant history of physical or psychiatric illness, any medical disorder that may make the participant unlikely to fully complete the study, or any condition that presents undue risk from the investigational product or procedures.
Have known or suspected intolerance or hypersensitivity to the investigational product, closely related compounds, or any of the stated ingredients.
Prior enrollment in a FST-100 or SHP640 clinical study.
Participants who are employees, or immediate family members of employees (who are directly related to study conduct), at the investigational site.
Have a history of ocular surgical intervention within <= 6 months prior to Visit 1 or planned for the period of the study.
Have a preplanned overnight hospitalization during the period of the study.
Have presence of any intraocular, corneal, or conjunctival ocular inflammation (example [eg,] uveitis, iritis, ulcerative keratitis, chronic blepharoconjunctivitis), other than bacterial conjunctivitis.
Have active or a history of ocular herpes.
Have at enrollment or within <= 30 days of Visit 1, a clinical presentation more consistent with the diagnosis of non-infectious conjunctivitis (except presumed seasonal/perennial allergic conjunctivitis) or non-bacterial ocular infection (eg, viral, fungal, acanthamoebal, or other parasitic). Note: history or concomitant presence of presumed seasonal or perennial allergic conjunctivitis signs/symptoms is not exclusionary.
Neonates or infants (ie, participants less than 12 months of age) who have suspected or confirmed (based on the result of any test conducted prior to screening) conjunctivitis of gonococcal, chlamydial, herpetic or chemical origin.
Neonates or infants (ie, participants less than 12 months of age) whose birth mothers had any sexually transmitted disease within 1 month of delivery or any history of genital herpes.
Presence of nasolacrimal duct obstruction at Visit 1 (Day 1).
Presence of any significant ophthalmic condition (eg, Retinopathy of Prematurity, congenital cataract, congenital glaucoma) or other congenital disorder with ophthalmic involvement that could affect study variables.
Be a known intraocular pressure (IOP) steroid responder, have a known history or current diagnosis of glaucoma or be a glaucoma suspect.
Have any known clinically significant optic nerve defects.
Have a history of recurrent corneal erosion syndrome, either idiopathic or secondary to previous corneal trauma or dry eye syndrome; presence of corneal epithelial defect or any significant corneal opacity at Visit 1.
Presence of significant, active condition in the posterior segment that requires invasive treatment (eg, intravitreal treatment with vascular endothelial growth factor inhibitors or corticosteroids) and may progress during the study participation period.
Have used any topical ocular or systemic antibiotics within <= 7 days of enrollment.
Have used any topical ocular non-steroidal anti-inflammatory drugs within <= 1 day of enrollment.
Have used any topical ophthalmic steroids in the last <= 14 days.
Have used any systemic corticosteroid agents within <= 14 days of Day 1. Stable (initiated >= 30 days prior to enrollment) use of inhaled and nasal corticosteroids is allowed, given no anticipated change in dose for the duration of the study. Topical dermal steroids are allowed except in the periocular area.
Have used non-corticosteroid immunosuppressive agents within <= 14 days of Day 1.
Have used any topical ophthalmic products, including tear substitutes, and over-the-counter preparations such as lid scrubs, within 2 hours of Visit 1 and be unable to discontinue all topical ophthalmic products for the duration of the study. Use of hot or cold compresses is also not permitted during the study.
Have any significant ocular disease (eg, Sjogren's syndrome) or any uncontrolled systemic disease or debilitating disease (eg, cardiovascular disease, hypertension, sexually transmitted diseases/infections, diabetes, or cystic fibrosis) that may affect the study parameters, per investigator's discretion.
Any known history of immunodeficiency disorder or known active conditions predisposing to immunodeficiency, such as human immunodeficiency virus, hepatitis B or C, evidence of active hepatitis A (anti-hepatitis A virus immunoglobulin M), or organ or bone marrow transplantation.
Within 30 days prior to the first dose of investigational product:
1. Have used an investigational product or device, or
2. Have been enrolled in a clinical study (including vaccine studies) that, in the investigator's opinion, may impact this Shire-sponsored study.

Study & Design

Study Type: INTERVENTIONAL

Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
PVP-I 0.6%	PVP-I 0.6%	Participants will instill 1 drop of PVP-I 0.6% ophthalmic solution in each eye 4 times QID for 7 days
Placebo	Placebo	Participants will instill 1 drop of placebo ophthalmic solution in each eye 4 times QID for 7 days.
SHP640	SHP640	Participants will instill 1 drop of SHP640 (povidone-iodine \[PVP-I\] 0.6 percent \[%\] and Dexamethasone 0.1%) ophthalmic suspension in each eye 4 times daily (QID) for 7 days.

Primary Outcome Measures

Name	Time	Method
Number of Participants With Clinical Resolution Among Who Received SHP640 or Placebo on Day 5	Day 5	Clinical resolution was defined as absence (score=0) of bulbar conjunctival injection and ocular conjunctival discharge in the study eye. Bulbar conjunctival injection was assessed based on 0 (Normal conjunctival vascular pattern) - 4 (Markedly prominent, intense diffuse hyperemia) scale which used pictures from validated bulbar redness (VBR) scale. Ocular conjunctival discharge was assessed based on 0 (No evidence of discharge in conjunctiva) - 3 (Abundant quantity of mucopurulent or purulent discharge) scale. The study eye was defined as an eye with score of at least 1 for both ocular conjunctival discharge and bulbar conjunctival redness at baseline. Data analysis was performed in SHP640 and placebo reporting groups only but not in PVP-I 0.6%.

Secondary Outcome Measures

Name	Time	Method
Number of Participants With Bacterial Eradication Among Who Received SHP640 or Placebo on Day 5	Baseline, Day 5	Bacterial eradication was defined as absence of all bacterial species present at or above pathological threshold at baseline in the study eye. Bacterial species were identified by Matrix Assisted Laser Desorption/Ionization-Time of Flight Mass Spectrometry, using their unique protein patterns. Pathological threshold for individual bacterial species was based on colony-forming unit (CFU)/mL threshold levels established by Cagle and modified by Leibowitz for different ocular bacterial species found in the specimens collected from each participant. Data analysis was performed in SHP640 and placebo reporting groups only but not in PVP-I 0.6%.
Change From Baseline in the Bulbar Conjunctival Injection Score	Baseline, Day 3, 5, 8 and 12	Bulbar conjunctival injection was assessed based on 0 (Normal conjunctival vascular pattern) - 4 (Markedly prominent, intense diffuse hyperemia) scale which used pictures from VBR scale.
Number of Participants With Modified Clinical Resolution	Day 3, 5, 8 and 12	Modified clinical resolution was defined as a global clinical score of 0 or 1. Global clinical score was defined as the sum of bulbar conjunctival injection and ocular conjunctival discharge scores. Global clinical score was defined as the sum of bulbar conjunctival injection and ocular conjunctival discharge scores. Bulbar conjunctival injection was assessed based on 0 (Normal conjunctival vascular pattern) - 4 (Markedly prominent, intense diffuse hyperemia) scale which used pictures from VBR scale. Ocular conjunctival discharge was assessed based on 0 (No evidence of discharge in conjunctiva) - 3 (Abundant quantity of mucopurulent or purulent discharge) scale.
Number of Participants With Clinical Resolution	Day 3, 8 and 12	Clinical resolution was defined as absence (score=0) of bulbar conjunctival injection and ocular conjunctival discharge in the study eye. Bulbar conjunctival injection was assessed based on 0 (Normal conjunctival vascular pattern) - 4 (Markedly prominent, intense diffuse hyperemia) scale which used pictures from VBR scale. Ocular conjunctival discharge was assessed based on 0 (No evidence of discharge in conjunctiva) - 3 (Abundant quantity of mucopurulent or purulent discharge) scale. The study eye was defined as an eye with score of atleast 1 for both ocular conjunctival discharge and bulbar conjunctival redness at baseline.
Global Clinical Score	Day 3, 5, 8 and 12	Global clinical score was defined as the sum of bulbar conjunctival injection and ocular conjunctival discharge scores. Bulbar conjunctival injection was assessed based on 0 (Normal conjunctival vascular pattern) - 4 (Markedly prominent, intense diffuse hyperemia) scale which used pictures from VBR scale. Ocular conjunctival discharge was assessed based on 0 (No evidence of discharge in conjunctiva) - 3 (Abundant quantity of mucopurulent or purulent discharge) scale. The study eye was defined as an eye with a score of at least 1 for both ocular conjunctival discharge and bulbar conjunctival redness at baseline.
Number of Participants With Treatment-emergent Adverse Events (TEAEs)	From start of study drug administration up to 14 days	An adverse event (AE) was any untoward medical occurrence in a clinical investigation participant administered a pharmaceutical product and that does not necessarily have a causal relationship with this treatment. Any AE that occured after the first dose of investigational product instillation was considered a TEAE.
Number of Participants With Bacterial Eradication	Day 3, 8 and 12	Bacterial eradication was defined as absence of all bacterial species present at or above pathological threshold at baseline in the study eye. Bacterial species were identified by Matrix Assisted Laser Desorption/Ionization-Time of Flight Mass Spectrometry, using their unique protein patterns. Pathological threshold for individual bacterial species was based on CFU/mL threshold levels established by Cagle and modified by Leibowitz for different ocular bacterial species found in the specimens collected from each participant.
Bulbar Conjunctival Injection Score	Day 3, 5, 8 and 12	Bulbar conjunctival injection was assessed based on 0 (Normal conjunctival vascular pattern) - 4 (Markedly prominent, intense diffuse hyperemia) scale which used pictures from VBR scale.
Ocular Conjunctival Discharge Score	Day 3, 5, 8 and 12	Ocular conjunctival discharge was assessed based on a 0 (No evidence of discharge in the conjunctiva) - 3 (Abundant quantity of mucopurulent or purulent discharge) scale.
Change From Baseline in the Ocular Conjunctival Discharge Score	Baseline, Day 3, 5, 8 and 12	Ocular conjunctival discharge was assessed based on a 0 (No evidence of discharge in the conjunctiva) - 3 (Abundant quantity of mucopurulent or purulent discharge) scale.
Change From Baseline in the Global Clinical Score	Baseline, Day 3, 5, 8 and 12	Global clinical score was defined as the sum of bulbar conjunctival injection and ocular conjunctival discharge scores. Bulbar conjunctival injection was assessed based on 0 (Normal conjunctival vascular pattern) - 4 (Markedly prominent, intense diffuse hyperemia) scale which used pictures from VBR scale. Ocular conjunctival discharge was assessed based on 0 (No evidence of discharge in conjunctiva) - 3 (Abundant quantity of mucopurulent or purulent discharge) scale. The study eye was defined as an eye with a score of at least 1 for both ocular conjunctival discharge and bulbar conjunctival redness at baseline.
Number of Participants With Expanded Clinical Resolution	Day 3, 5, 8 and 12	Expanded clinical resolution was defined as a global clinical score of 0, 1, or 2 with neither injection nor discharge having a score of 2. Global clinical score was defined as the sum of bulbar conjunctival injection and ocular conjunctival discharge scores. Bulbar conjunctival injection was assessed based on 0 (Normal conjunctival vascular pattern) - 4 (Markedly prominent, intense diffuse hyperemia) scale which used pictures from VBR scale. Ocular conjunctival discharge was assessed based on 0 (No evidence of discharge in conjunctiva) - 3 (Abundant quantity of mucopurulent or purulent discharge) scale.
Time to Clinical Resolution	Baseline to Day 12	Clinical resolution was defined as absence (score of 0) of bulbar conjunctival injection and ocular conjunctival discharge in the study eye. Bulbar conjunctival injection was assessed based on 0 (Normal conjunctival vascular pattern) - 4 (Markedly prominent, intense diffuse hyperemia) scale which used pictures from VBR scale. Ocular conjunctival discharge was assessed based on 0 (No evidence of discharge in conjunctiva) - 3 (Abundant quantity of mucopurulent or purulent discharge) scale. Time to clinical resolution defined as the date on which a participant first reached clinical resolution minus the date of first dose of investigational product, plus 1.
Number of Participants Who Used Rescue Medication	Baseline to Day 12	Rescue treatment with a licensed antibiotic according to the local standard of care was provided to participants if, in the judgment of the investigator, there was no clinical improvement or worsening of their condition to an extent that it would be in the best interest of the participant treated with an alternate therapy for safety reasons.

Trial Locations

Locations (161): Sok H. Nam, M.D. Inc.
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Los Angeles, California, United States
Danbury Eye Physicians and Surgeons
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Danbury, Connecticut, United States
Instituto Oftalmológico Fernández-Vega
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Oviedo, Asturias, Spain
Baker, Carl W
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Paducah, Kentucky, United States
Mercy Research
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Springfield, Missouri, United States
UPMC Eye Center
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Pittsburgh, Pennsylvania, United States
Houston Eye Associates
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Houston, Texas, United States
Advanced Laser Vision & Surgical Institute
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Houston, Texas, United States
Millenium Clinical Research
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Miami, Florida, United States
Lorites Medical Group
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Miami, Florida, United States
Apex Eye
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Cincinnati, Ohio, United States
Sabates Eye Centers
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Leawood, Kansas, United States
The Ohio State University
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Columbus, Ohio, United States
IPS Research Company*
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Oklahoma City, Oklahoma, United States
Nashville Vision Associates
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Nashville, Tennessee, United States
Toyos Clinic
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Nashville, Tennessee, United States
Sun Research Institute, LLC
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San Antonio, Texas, United States
R and R Eye Research, LLC.
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San Antonio, Texas, United States
Jean Brown Research
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Salt Lake City, Utah, United States
WCCT Global (PH 1 Unit)
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Santa Ana, California, United States
East West Eye Institute
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Torrance, California, United States
Macy Eye Center
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Los Angeles, California, United States
Lugene Eye Institute Inc
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Glendale, California, United States
North Bay Eye Associates, Inc.
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Petaluma, California, United States
Inland Eye Specialists
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Hemet, California, United States
Lakeside Vision Center
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Irvine, California, United States
Mark B. Kislinger, MD, Inc.
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Glendora, California, United States
Clark S Tsai Eye Center
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Concord, California, United States
Wohl Eye Center
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Bloomingdale, Illinois, United States
Shasta Eye Medical Group, Inc.
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Redding, California, United States
Ophthalmic Consultants of Connecticut
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Meriden, Connecticut, United States
The Eye Associates of Manatee, LLP
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Bradenton, Florida, United States
Bowden Eye & Associates
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Jacksonville, Florida, United States
Shettle Eye Research, Inc.
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Largo, Florida, United States
Saltzer Medical Group
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Nampa, Idaho, United States
Logan Ophthalmic Research, LLC
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Tamarac, Florida, United States
MediSphere Medical Research Center, LLC
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Evansville, Indiana, United States
East Florida Eye Institute
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Stuart, Florida, United States
Kannarr Eye Care
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Pittsburg, Kansas, United States
Lakeview Vision
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Gretna, Louisiana, United States
Andrew Gardner Logan, MD / dba Logan Ophthalmic Research, LLC
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Tamarac, Florida, United States
Midwest Cornea Associates, LLC
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Indianapolis, Indiana, United States
Cincinnati Eye Institute
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Cincinnati, Ohio, United States
Illinois Eye Center
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Peoria, Illinois, United States
Eye Center Northeast
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Bangor, Maine, United States
Koffler Vision Group
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Lexington, Kentucky, United States
NECCR PrimaCare Research
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Fall River, Massachusetts, United States
NV Eye Physicians
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Henderson, Nevada, United States
Farkas, Kassalow, Resnick &Associates
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New York, New York, United States
HaEmek Medical Center
🇮🇱
Afula, Israel
Cleveland Eye Clinic
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Cleveland, Ohio, United States
Wellish Vision Institute
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Las Vegas, Nevada, United States
Apex Eye Kenwood
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Cincinnati, Ohio, United States
Philadelphia Eye Associates
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Philadelphia, Pennsylvania, United States
Fichte, Endl& Elmer Eyecare
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Niagara Falls, New York, United States
Northern New Jersey Eye Institute
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South Orange, New Jersey, United States
The Columbus Eye Center
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Columbus, Ohio, United States
Pacific Clear Vision Institute
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Eugene, Oregon, United States
Matossian Eye Associates
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Doylestown, Pennsylvania, United States
Centrum Medyczne Uno-Med
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Tarnów, Poland
Soroka University Medical Center
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Beer Sheva, Israel
Szpital Specjalistyczny nr 1
🇵🇱
Bytom, Poland
Centrum Diagnostyki i Mikrochirurgii Oka LENS
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Olsztyn, Poland
Retina Sp. z o.o.
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Warszawa, Poland
A.O.U. Policlinico San'Orsola-Malpighi
🇮🇹
Bologna, Italy
Berrocal and Associates
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San Juan, Puerto Rico
Clinica Rementeria
🇪🇸
Madrid, Spain
Cartujavision
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Sevilla, Spain
Emanuelli Research & Development Center, LLC
🇵🇷
Arecibo, Puerto Rico
Into Research
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Pretoria, Gauteng, South Africa
Clinica Oftalmologia Gil Piña
🇪🇸
Huelva, Spain
Minnesota Eye Consultants, P.A
🇺🇸
Bloomington, Minnesota, United States
Sacramento Eye Consultants
🇺🇸
Sacramento, California, United States
International Research Center
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Tampa, Florida, United States
Eye Physicians of Long Beach
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Long Beach, California, United States
Cornea and Cataract Consultants of Arizona
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Phoenix, Arizona, United States
M&M Eye Institute
🇺🇸
Prescott, Arizona, United States
Arizona Eye Center
🇺🇸
Chandler, Arizona, United States
Schwartz Laser Eye Center
🇺🇸
Scottsdale, Arizona, United States
Walman Eye Center
🇺🇸
Sun City, Arizona, United States
Hull Eye Center
🇺🇸
Lancaster, California, United States
Milton M. Hom, OD, FAAO
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Azusa, California, United States
North Valley Eye Medical Group Inc
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Mission Hills, California, United States
Arch Health Partners
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Poway, California, United States
Wolstan & Goldberg Eye Associates
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Torrance, California, United States
Specialty Eye Care
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Parker, Colorado, United States
Bruce A. Segal, MD, PA
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Delray Beach, Florida, United States
Windham Eye Group
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Willimantic, Connecticut, United States
South Florida Vision
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Fort Lauderdale, Florida, United States
Bascom Palmer Eye Institute
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Miami, Florida, United States
Medsol Clinical Research Center
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Port Charlotte, Florida, United States
Millennium Clinical Research, Inc.
🇺🇸
Miami, Florida, United States
South Florida Research Center Inc.
🇺🇸
Miami, Florida, United States
Score Physician Alliance, LLC
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Saint Petersburg, Florida, United States
Jackson Eye
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Lake Villa, Illinois, United States
Kentucky Eye Institute
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Lexington, Kentucky, United States
Lifelong Vision Foundation
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Chesterfield, Missouri, United States
Opthalmology Consultants Ltd.
🇺🇸
Saint Louis, Missouri, United States
Emil A. Stein, M.D., Ltd.
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Las Vegas, Nevada, United States
Hassman Research Institute
🇺🇸
Berlin, New Jersey, United States
South Shore Eye Care
🇺🇸
Wantagh, New York, United States
Oculus Research at Garner EyeCareCenter
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Raleigh, North Carolina, United States
Wyomissing Optometric Center
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Wyomissing, Pennsylvania, United States
Black Hills Regional Eye Institute
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Rapid City, South Dakota, United States
Total Eye Care, PA
🇺🇸
Memphis, Tennessee, United States
Eye Specialty Group
🇺🇸
Memphis, Tennessee, United States
Lake Travis Eye & Laser Center
🇺🇸
Lakeway, Texas, United States
Eyeland Vision
🇺🇸
El Paso, Texas, United States
Ericksen Research & Development, LLC
🇺🇸
Clinton, Utah, United States
Emerson Clinical Research Institute
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Falls Church, Virginia, United States
Piedmont Eye Center, Inc.
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Lynchburg, Virginia, United States
Augenklinik, Studienzentrum, Kepler-Universitätsklinikum GmbH
🇦🇹
Linz, Austria
University of Wisconsin
🇺🇸
Madison, Wisconsin, United States
AKH - Medizinische Universitaet Wien
🇦🇹
Vienna, Austria
Vienna Institute for Research in Ocular Surgery
🇦🇹
Vienna, Austria
University of Waterloo School of Optometry and Vision Science
🇨🇦
Waterloo, Ontario, Canada
The Ottawa Hospital - General Campus, University of Ottawa Eye Institute
🇨🇦
Ottawa, Ontario, Canada
Eye Clinic Dr Kirsta Turman (Kreutzwaldi Silmakeskus)
🇪🇪
Tallinn, Estonia
East Tallinn Central Hospital Eye Clinic
🇪🇪
Tallinn, Estonia
Tartu University Hospital
🇪🇪
Tartu, Estonia
Kaposi Mór Hospital
🇭🇺
Kaposvár, Hungary
Bugat Pal Hospital Clinexpert Gyongyos
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Gyongyos, Heves, Hungary
Rambam MC
🇮🇱
Haifa, Israel
Kaplan Medical Center
🇮🇱
Rehovot, Israel
Rabin Medical Center-Beilinson Campus.
🇮🇱
Petah Tikva, Israel
Sharey Zedek MC
🇮🇱
Jerusalem, Israel
Tel Aviv Medical Center
🇮🇱
Tel Aviv, Israel
Centro Dotal de Investigaciones de Servicios de Salud
🇵🇷
Carolina, Puerto Rico
Newtown Clinical Research Centre
🇿🇦
Johannesburg, Gauteng, South Africa
Pretoria Eye Institute
🇿🇦
Pretoria, Gauteng, South Africa
Clinical Trials Research
🇺🇸
Roseville, California, United States
Eye Care Centers Management, Inc.
🇺🇸
Morrow, Georgia, United States
Oxford Optical
🇺🇸
Los Angeles, California, United States
University of Southern California
🇺🇸
Los Angeles, California, United States
Washington University
🇺🇸
Saint Louis, Missouri, United States
Tekwani Vision Center
🇺🇸
Saint Louis, Missouri, United States
Martel Eye Medical Group
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Rancho Cordova, California, United States
Clinical Eye Research of Boston
🇺🇸
Winchester, Massachusetts, United States
Shire Call Center
🇺🇸
Lexington, Massachusetts, United States
Eye Associates of Northeast Louisiana dba Haik Humble Eye Center
🇺🇸
West Monroe, Louisiana, United States
Ophthalmology Associates
🇺🇸
Saint Louis, Missouri, United States
Chrysalis Clinical Research
🇺🇸
Saint George, Utah, United States
SkyVision Centers
🇺🇸
Westlake, Ohio, United States
Lone Star Eye Care, P.A.
🇺🇸
Sugar Land, Texas, United States
DCT- Shah Research, LLC dba Discovery Clinical Trials
🇺🇸
Mission, Texas, United States
The Eye Institute of Utah
🇺🇸
Salt Lake City, Utah, United States
CHU Limoges - Hopital Dupuytren
🇫🇷
Limoges, Haute Vienne, France
University of the Sunshine Coast Clinical Trials Centre
🇦🇺
Sippy Downs, Queensland, Australia
Pediatric & Adult Research Center, LLC
🇺🇸
Orlando, Florida, United States
Senior Health Services
🇺🇸
Louisville, Kentucky, United States
The Eye Care Institute
🇺🇸
Louisville, Kentucky, United States
Dr. Haider Eye Care
🇺🇸
Louisville, Kentucky, United States
James Branch, M.D.
🇺🇸
Winston-Salem, North Carolina, United States
Massachusetts Eye and Ear Infirmary
🇺🇸
Boston, Massachusetts, United States
SZTE Szemeszeti Klinika
🇭🇺
Szeged, Csongrad, Hungary
Debreceni Egyetem
🇭🇺
Debrecen, Hungary
Csolnoky Ferenc Korhaz
🇭🇺
Veszprem, Hungary
Jenkins Eye Care
🇺🇸
Honolulu, Hawaii, United States
Silverstein Eye Centers
🇺🇸
Kansas City, Missouri, United States
Moyes Eye Center
🇺🇸
Kansas City, Missouri, United States
Bluestein Custom Vision
🇺🇸
Charleston, South Carolina, United States