NCT00576030TerminatedNot Applicable
Short-term Autonomic Effects of Caffeinated and Decaffeinated Espresso in Young Healthy Individuals
Charite University, Berlin, Germany1 site in 1 country77 target enrollmentStarted: January 1, 2007Last updated:
Conditions
Interventions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Terminated
- Enrollment
- 77
- Locations
- 1
- Primary Endpoint
- Heart rate variability
Study Overview
Brief Summary
More than 80% of the population in the USA consume coffee each day. However there not many studies on change of heart rate variability and placebo effects after consumption of coffee.
In our study we aim to test the following hypotheses:
- Habitual caffeinated espresso coffee drinkers show an increase in blood pressure, heart rate variability and parasympathetic activity (high frequency band) of the heart.
- Non-habitual caffeinated espresso coffee drinkers show an increase of blood pressure. The heart rate variability and the parasympathetic activity of the heart will decrease.
- Caffeinated or decaffeinated espresso induces comparable changes in habitual or non-habitual coffee drinkers.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Basic Science
- Masking
- Triple (Participant, Care Provider, Investigator)
Eligibility Criteria
- Ages
- 18 Years to 50 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •18- 50 years old, healthy
Exclusion Criteria
- •Medication, obese(BMI > 30)
Arms & Interventions
H
Other
habitual coffee drinkers
Intervention: hab cof with water (Other)
H
Other
habitual coffee drinkers
Intervention: hab cof with dec espresso (Other)
H
Other
habitual coffee drinkers
Intervention: hab cof with caf espresso (Other)
N
Other
non-habitual coffee drinkers
Intervention: non-hab cof with water (Other)
N
Other
non-habitual coffee drinkers
Intervention: non-hab cof with dec espresso (Other)
N
Other
non-habitual coffee drinkers
Intervention: non-hab cof with caf espresso (Other)
Outcomes
Primary Outcomes
Heart rate variability
Time Frame: 70 minutes
Secondary Outcomes
- blood pressure(70 min.)
Investigators
Study Sites (1)
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