Comparison of the efficacy and safety of steroid-impregnated self-crosslinked hyaluronic acid (PureRegen®) and steroid-impregnated bioabsorbable polyurethane foam (Nasopore®) in adults undergoing functional endoscopic sinus surgery (FESS) for chronic rhinosinusitis (CRS): a randomised controlled trial.

Gosford Hospital0 个研究点目标入组 60 人开始时间: 2021年4月6日最近更新: 2021年4月12日

适应症

试验速览

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•1)CT Lund-Mackay score was greater and equal to 1, AND
•2)Minimum trial of at least eight weeks’ duration of a topical intranasal corticosteroid, AND
•3)Short course of systemic corticosteroid (CRSwNP) OR either a short-course of a broad spectrum / culture-directed systemic antibiotic OR the use of a prolonged course of systemic low-dose anti-inflammatory antibiotic (CRSsNP)
•4)Post-medical treatment total SNOT-22 score greater than or equal to 20.

•-Immunodeficiency
•-Cystic fibrosis
•-Rhinologic granulomatous disease
•-Use of oral/nasal steroids from 30 days preoperatively to 30 days postoperatively
•-Previous sinus surgery
•-Aspirin intolerance
•-Mucociliary disorder
•-History of Glaucoma
•-Unable to provide informed consent
•-Unable to commit to attending follow-up appointments

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