Clinical Study on the Protection of Intestinal Barrier Function of Patients with Sepsis by Acupuncture Combined Medicine Therapy

Phase 1

Recruiting

• Conditions: Sepsis

• Registration Number: ITMCTR2100004754
• Lead Sponsor: Beijing University of Chinese Medicine Shenzhen Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

1. Meet the diagnostic criteria of sepsis;
2. Combined with gastrointestinal dysfunction;
3. Meet the diagnostic criteria of TCM Yang deficiency syndrome;
4. Aged between 18-80 years;
5. Patients or family members sign informed consent.

Exclusion Criteria

1. Primary digestive tract inflammation;
2. Patients with intestinal dysfunction after gastrointestinal surgery;
3. Patients with advanced tumor;
4. Patients with primary heart, liver, kidney, brain, and blood system serious basic diseases;
5. Contraindications to enteral nutrition;
6. Intolerant to acupuncture;
7. Those who have been admitted to the ICU for less than 4 days.

Study & Design

• Study Type: Interventional study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Serum index detection of intestinal mucosal barrier function (serum I-FABP, ZO-1, Occludin, LPS levels);Gastrointestinal dysfunction score (fasting, reflux, gastrointestinal decompression, gastric retention, abdominal distension, abdominal pain, diarrhea, weakened bowel sounds, disappearance of bowel sounds, and constipation);Immunological index detection (peripheral blood CD4+, CD8+, Treg, Th17 cells, serum IL-10);Traditional Chinese Medicine Syndrome Scores;Serum inflammatory factor detection (TLR-4, NF -?B, IL-6);Routine evaluation index of sepsis (PCT, CRP);Colony count of intestinal flora;