A Study of LY3484356 in Chinese Participants With Advanced Breast Cancer
- Registration Number
- NCT05509790
- Lead Sponsor
- Eli Lilly and Company
- Brief Summary
This is a study of LY3484356 in Chinese participants with advanced breast cancer. Participants must have breast cancer that is estrogen receptor positive (ER+), HER2 negative (HER2-). The purpose of this study is to measure how much LY3484356 gets into the bloodstream and how long it takes the body to remove it. The safety and effectiveness of LY3484356 will also be studied. Participation could last up to 28 months.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 17
- Native Chinese participants must be of an acceptable age to provide informed consent
- Have locally advanced (not amenable to curative treatment by surgery) or metastatic disease and be an appropriate candidate for experimental therapy in the judgment of the investigator, after available standard therapies have ceased to provide clinical benefit
- Have a diagnosis of ER+, HER2- breast cancer
- Female participants have postmenopausal status due either surgical/natural menopause or ovarian suppression
- If postmenopausal status is due to ovarian suppression, participants must have a negative serum pregnancy test and agree to use highly effective, medically approved precautions to prevent pregnancy
- Have a performance status less than or equal to (≤)1 on the Eastern Cooperative Oncology Group (ECOG) scale
- Have adequate organ function
- Must be able to swallow capsules/tablets
-
Have symptomatic central nervous system (CNS) metastasis and/or carcinomatous meningitis
-
Have a serious concomitant systemic disorder
- Human immunodeficiency virus (HIV) positive patients are excluded unless they are well controlled on highly active antiretroviral therapy with no evidence of autoimmune deficiency syndrome-defining opportunistic infections within the last 2 years, and cluster of differentiation 4 (CD4) count greater than (>)350 cells/microliter (μL)
- Active hepatitis B or C virus infection
- Severe renal impairment, interstitial lung disease, severe dyspnea at rest or requiring oxygen therapy, history of major surgical resection involving the stomach or small bowel, preexisting Crohn's disease or ulcerative colitis or a preexisting chronic condition resulting in clinically significant diarrhea
-
Have visceral crisis
-
Have a serious cardiac condition
-
Have an acute leukemia or other relevant cancers
-
Females who are pregnant or lactating
-
Known allergic reaction against any of the components of the study drug
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description LY3484356 Dose Level 1 LY3484356 Administered orally. LY3484356 Dose Level 2 LY3484356 Administered orally.
- Primary Outcome Measures
Name Time Method Pharmacokinetics (PK): Plasma Concentration of LY3484356 Time Frame: Cycle 1, Day 1 through Day 3 and Day 17 through Day 18; Cycle 2 Day 1 (Cycle 1 = 30 days, Cycle 2 = 28 days) PK: Plasma Concentration of LY3484356
- Secondary Outcome Measures
Name Time Method 2. Percentage of Participants Who Achieve a Best Overall Response (BOR) of Complete Response (CR) or Partial Response (PR): Overall Response Rate (ORR) Randomization to Disease Progression or Death from Any Cause (Estimated up to 28 months) ORR
Disease Control Rate (DCR): Percentage of Participants With a BOR of Complete Response (CR), Partial Response (PR) or Stable Disease (SD) Randomization to Disease Progression or Death from Any Cause (Estimated up to 28 months) DCR
Progression-Free Survival (PFS) Randomization to Disease Progression or Death from Any Cause (Estimated up to 28 months) PFS
Trial Locations
- Locations (4)
Hunan Cancer Hospital
🇨🇳Changsha, Hunan, China
Wannan Medical College Yijishan Hospital
🇨🇳Wuhu Shi, Anhui, China
The Third Hospital of Nanchang
🇨🇳Nanchang, Jiangxi, China
Fudan University Shanghai Cancer Center
🇨🇳Shanghai, Shanghai, China