Surveillance Monitoring for ART Toxicities Study in HIV Uninfected Children Born to HIV Infected Women
- Conditions
- Antiretroviral Toxicity
- Registration Number
- NCT01310023
- Lead Sponsor
- Harvard School of Public Health (HSPH)
- Brief Summary
SMARTT will estimate the incidence of conditions and diagnoses potentially related to in utero exposure to antiretroviral therapy and/or exposure in the first two months of life among children born of HIV-infected mothers.
- Detailed Description
Many antiretroviral therapy (ART) medications given to a pregnant woman cross the placenta and can be detected in the amniotic fluid and cord blood resulting in substantial fetal exposure. Therefore, there is concern about toxicity of the drugs in the fetus and infant. It is noteworthy that none of the currently approved ART medications for the prevention of maternal to fetal transmission of HIV are in Food and Drug Administration (FDA) Pregnancy Category A (no fetal risk ascertained in adequately controlled human studies). Thus, there is continued need to examine the toxicity of ART in HIV transmission prevention for the short-term toxicity of newer agents and combinations as well as the unanswered questions of longer term toxicity and subtle adverse effects.
The study will use a registry approach to conduct active surveillance among children \< 12 years of age at enrollment. Occurrences of abnormalities from ART exposure in utero and/or in the first two months of life will be sought in multiple domains, including metabolic, growth, cardiac, neurologic, neurodevelopmental, behavior, language, and hearing. Clinical and laboratory data will be examined for abnormalities through a hierarchy of evaluations: adverse events (AE) will be identified → selected AEs will trigger predefined additional evaluations → significant observations will be defined as cases → a pattern of significant study-wide cases will be defined as signals. The incidence of these events of interest will be monitored over time and by ART regimen, and compared with historical data that may be suggestive of a signal. Some signals may be testable using existing and/or previously collected data, while other signals may indicate the need for additional hypothesis-driven studies outside of SMARTT.
The objectives of SMARTT are:
1. To estimate the occurrence of potential ART-related toxicities through an ongoing surveillance system among HIV-uninfected children born to mothers with HIV infection with and without exposure to ART in utero and/or in the first two months of life and compare the occurrences of these outcomes with other sources of data as well as by ART exposures; and
2. To actively encourage hypothesis-driven studies to confirm that the signals are due to ART exposure in utero and/or in the first two months of life. Note that the full design and execution of these studies may be beyond the scope of the SMARTT study but will be facilitated by SMARTT.
The specific aims of SMARTT are:
1. To create a Static Surveillance Cohort to extend domain-specific data collection in children either 1) previously enrolled in any of the approved studies for enrollment into SMARTT; 2) previously enrolled in another pediatric HIV/AIDS cohort study with SMARTT Protocol Chair approval, or 3) not previously enrolled in an approved study but with equivalent data available in the medical record;
2. To create a Dynamic Surveillance Cohort to examine domain-specific data of children newly exposed to ART in utero and/or in the first two months of life;
3. To create a Young Adult Cohort to study long-term outcomes in SMARTT participants formerly enrolled in the Static and Dynamic cohorts.
4. To identify a set of "triggers" for each domain that define a "signal" of possible ART toxicity and compare the occurrence of these signals with previously collected data and by ART exposure; and
5. To encourage and facilitate the development of hypothesis-driven studies to evaluate whether a "signal" is the result of ART exposure in utero and/or in the first two months of life.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 5170
Dynamic Cohort:
- HIV-exposed living fetus greater than or equal to 23 weeks gestation or a live infant born after 22 weeks gestation. Infants exposed and unexposed to ART will be enrolled.
- Any infant born of an HIV-infected mother may be enrolled pending determination of the infant's HIV infection status. However, infants found to be HIV-positive will be discontinued from the study and will be referred for care outside this study. HIV infection status will be determined using the Diagnosis of Lack of Infection in HIV-Exposed Children.
- ART exposure data by trimester of pregnancy must be available if ART exposed.
- Entry prior to birth through < 72 hours of age.
- Willingness of parent/legal guardian to provide written permission for child to participate in study.
- Willingness of biological mother to enroll at initial enrollment of her child.
Dynamic Cohort:
None
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Abnormal organ function Birth and age one, semiannual thereafter. Assessed through the measurement of lipase, CPK, ALT, creatinine, glucose, LDH, BUN, WBC, PMN, lymphocytes, platelets, or hemoglobin ( ≥ Grade 3 adverse event).
Drug Use and Sexual Activity 11, 13, 15, and 17 years of age. The assessment of sexual behavior and substance use will be conducted using an Audio Computer Assisted Survey Instrument (ACASI). ACASI uses computer and voice recordings so that the participant hears (through headphones) and sees (on the screen) each question and response list. The use of ACASI is proven to minimize response bias due to the presence of an interviewer.
Abnormal growth and metabolic function Annually birth through age 5; semiannual thereafter, assessments vary based on age of child. Assessed through the measurement of height, weight, tricep skinfold thickness, mid-upperarm circumference measurements, insulin and glucose, and fasting lipids.
Cardiac abnormalities Ages 3-5. Assessed through the administration of echocardiograms and serum biomarkers (ProBNP).
Hearing dysfunction At age 5 and for children of all ages meeting a hearing/language trigger. Assessed via audiologic evaluation conducted by an audiologist.
Language dysfunction 1, 2, 3, 5, and 9 years of age, assessments vary based on age. Assessed via the following language tests: MCDI, Ages and Stages Communication Scale, PPVT IV, Goldman Fristoe 2, Rice Wexler, TELD-3, TOLD-3, Woodcock, CELF IV.
Death due to unknown medical condition Annual. Assessed through autopsy review.
Neurologic abnormalities Annually birth through age 5; semiannual thereafter, assessments vary based on age of child. Assessed via head circumference measurement and medical record review for documented clinical diagnoses of seizures, microcephaly, or other neurologic diagnosis.
Neurodevelopmental abnormalities 1, 3, 5, 9, and 13 years of age, assessments vary based on age of child. Assessed via the following neurodevelopmental tests: Bayley Screener, Bayley III, WPPSI-III, BASC-2, WASI, WISC-IV, BRIEF, WIAT II.
- Secondary Outcome Measures
Name Time Method Maternal substance use during pregnancy Entry visit. Obtained via interview, toxicology report, and meconium testing.
Trial Locations
- Locations (22)
University of Alabama
🇺🇸Birmingham, Alabama, United States
University of California San Diego
🇺🇸La Jolla, California, United States
University of Southern California
🇺🇸Los Angeles, California, United States
University of Colorado Denver Health Sciences Center
🇺🇸Aurora, Colorado, United States
Children's Diagnostic & Treatment Center
🇺🇸Fort Lauderdale, Florida, United States
University of Florida Health Science Center
🇺🇸Jacksonville, Florida, United States
University of Miami
🇺🇸Miami, Florida, United States
University of Illinois, Chicago
🇺🇸Chicago, Illinois, United States
Ann and Robert H. Lurie Children's Hospital
🇺🇸Chicago, Illinois, United States
Tulane University Health Sciences Center
🇺🇸New Orleans, Louisiana, United States
University of Maryland
🇺🇸Baltimore, Maryland, United States
Rutgers - New Jersey Medical School
🇺🇸Newark, New Jersey, United States
Bronx Lebanon Hospital Center
🇺🇸Bronx, New York, United States
Jacobi Medical Center
🇺🇸Bronx, New York, United States
SUNY Downstate Medical Center
🇺🇸Brooklyn, New York, United States
New York University School of Medicine
🇺🇸New York, New York, United States
SUNY Stony Brook
🇺🇸Stony Brook, New York, United States
Children's Hospital of Philadelphia
🇺🇸Philadelphia, Pennsylvania, United States
St. Jude Children's Research Hospital
🇺🇸Memphis, Tennessee, United States
Baylor College of Medicine
🇺🇸Houston, Texas, United States
University of Puerto Rico Medical Center
🇵🇷San Juan, Puerto Rico
San Juan Research Hospital
🇵🇷San Juan, Puerto Rico