A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of Niraparib Maintenance Treatment in Patients with Advanced Ovarian Cancer Following Response on Front-Line Platinum-Based Chemotherapy

Phase 1

• Conditions: Homologous recombination deficiency advanced ovarian cancer; MedDRA version: 20.0Level: PTClassification code: 10033128Term: Ovarian cancer Class: 100000004864; Therapeutic area: Diseases [C] - Neoplasms [C04]

• Registration Number: CTIS2023-508010-42-00
• Lead Sponsor: Tesaro Inc.

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-03-28
• Last Update Posted: 22 July 2024

Recruitment & Eligibility

• Status: ot Recruiting
• Sex: Not specified
• Target Recruitment: 1364

Inclusion Criteria

Patients must be female =18 years of age, able to understand the study procedures and agree to participate in the study by providing written informed consent., Patients of childbearing potential must have a negative serum or urine pregnancy test (beta human chorionic gonadotropin [hCG]) within 7 days prior to receiving the first dose of study treatment., Patients must be postmenopausal, free from menses for >1 year, surgically sterilized, or willing to use adequate contraception to prevent pregnancy or must agree to abstain from activities that could result in pregnancy throughout the study, starting with enrollment through 180 days after the last dose of study treatment., Patients must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1., Patients must be able to take oral medications., Patients must have adequate organ function, defined as follows (Note: complete blood count [CBC] test should be obtained without transfusion or receipt of stimulating factors within 2 weeks before obtaining screening blood sample): a. Absolute neutrophil count =1,500/µL b. Platelets =100,000/µL c. Hemoglobin =10 g/dL d. Serum creatinine =1.5 x upper limit of normal (ULN) or calculated creatinine clearance =60 mL/min using the Cockcroft-Gault equation. e. Total bilirubin =1.5 x ULN f. Aspartate aminotransferase and alanine aminotransferase =2.5 x ULN unless liver metastases are present, in which case they must be =5 x ULN., All patients must agree to complete PROs during study and then at 4 weeks, 8 weeks, 12 weeks, and 24 weeks after EOT, regardless of subsequent treatment., Patients must have formalin-fixed, paraffin-embedded tumor samples available from the primary cancer or agree to undergo fresh biopsy prior to study treatment initiation., Histological and staging criteria: a. Patients must have histologically diagnosed high-grade serous or endometrioid, or high-grade predominantly serous or endometrioid ovarian cancer, fallopian tube cancer, or primary peritoneal cancer that is Stage III or IV according to FIGO criteria., Surgical criteria: a. Patients with inoperable Stage III and IV disease are eligible; b. All Stage IV patients with operable disease are eligible; c. Patients with stage III or IV disease treated with neoadjuvant chemotherapy and interval debulking surgery are eligible; d. Patients with stage III disease who have visible residual disease after primary debulking surgery are eligible., Chemotherapy criteria: a. Patients who have received intraperitoneal chemotherapy are eligible; b. All patients must have had =6 and =9 cycles of platinum-based therapy; Patients must have had =2 post-operative cycles of platinum-based therapy following interval debulking surgery; d. Patients must have physician assessed CR or PR after =3 cycles of therapy; e. Patients must have either CA-125 in the normal range or CA-125 decrease by more than 90% during their front-line therapy that is stable for at least 7 days (i.e., no increase >15% from nadir)., Patients must be randomized within 12 weeks of the first day of the last cycle of chemotherapy., All patients must agree to undergo central tumor HRD testing. a. The central HRD test result must be available for randomization as it is a stratification factor. Patients with documented gBRCA1 or gBRCA2 mutation or sBRCA1/2 mutation may be randomized without HRD test results. b. The tumor sample may be submitted for HRD testing prior to the screening period if it appears the pati

Exclusion Criteria

Patient has mucinous or clear cell subtypes of epithelial ovarian cancer, carcinosarcoma or undifferentiated ovarian cancer, Patient has known brain or leptomeningeal metastases that are untreated or uncontrolled (i.e., new or worsening symptom or signs, or unstable steroid requirements), Patient is considered a poor medical risk due to a serious, uncontrolled medical disorder, nonmalignant systemic disease, or active, uncontrolled infection, Patient is to receive bevacizumab as maintenance treatment. Patients who have received bevacizumab with their first-line platinum-based therapy but are unable to receive bevacizumab as maintenance therapy due to adverse events or for any other reason are not excluded from study as long as the last dose of bevacizumab was received =28 days prior to signing the main informed consent form, Patient is immunocompromised (patients with splenectomy are allowed)., Patient has known, active hepatic disease (i.e., hepatitis B or C)., Patient has had investigational therapy administered within 4 weeks, or within a time interval less than at least 5 half-lives of the investigational agent, whichever is longer, prior to the first scheduled day of dosing in this study, Patient has undergone major surgery (per Investigator judgment) within 3 weeks of starting the study or patient has not recovered from any effects of any major surgery, Patient has had drainage of ascites within 4 weeks prior to enrollment, Patient has undergone palliative radiotherapy encompassing >20% of the bone marrow within 1 week of the first dose of study treatment, Patient has a condition (such as transfusion dependent anemia or thrombocytopenia), therapy, or laboratory abnormality that might confound the study results or interfere with the patient’s participation for the full duration of the study treatment, including: a. Patient received a transfusion (platelets or red blood cells) within 2 weeks of the first dose of study treatment; b. Patient received colony-stimulating factors (e.g., granulocyte colony stimulating factor [G-CSF], granulocyte macrophage colony-stimulating factor [GM-CSF] or recombinant erythropoietin) within 2 weeks prior to the first dose of study treatment., Patients with Stage III disease who have had complete cytoreduction (i.e., no visible residual disease) after primary debulking surgery, Patient has had any known =Grade 3 anemia, neutropenia or thrombocytopenia due to prior chemotherapy that persisted >4 weeks, Patient has any known history or current diagnosis of MDS or AML, Patient has a corrected QT interval (QTc) prolongation >480 milliseconds at screening, Patient has undergone more than two debulking surgeries, Patient is pregnant, breastfeeding, or expecting to conceive children while receiving study treatment and for up to 180 days after the last dose of study treatment, Patient has a known hypersensitivity to the components of niraparib or its excipients;, Patient is simultaneously enrolled in any clinical trial of niraparib or any other investigational therapy, Patient has received prior treatment with a known PARP inhibitor or has participated in a study where any treatment arm included administration of a known PARP inhibitor, Patient is planning to donate blood during the study or for 90 days after the last dose of study treatment., Patient has been diagnosed and/or treated for invasive cancer less than 5 years prior to study enrollment. Note: Patients with definitively treated uterine cervical or u

Study & Design

• Study Type: Interventional clinical trial of medicinal product
• Study Design: Not specified