The Effect of Hypochlorous Acid Spray on Ocular Symptoms and Eyelid Microbiota

Not Applicable

• Conditions: Dry eye disease; Eye - Diseases / disorders of the eye

• Registration Number: ACTRN12623000361606
• Lead Sponsor: SW Sydney

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-04-12
• Last Update Posted: 5 June 2023

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 44

Inclusion Criteria

• Adults aged 18 years or older.
• Able to read and comprehend English and provide informed consent by signing a record of informed consent.
• Habitual visual acuity of at least 6/9 in each eye
• Willingness to use hypochlorous acid spray on their eyelids twice daily for 4 weeks.
• Willingness to attend two clinic visits at the School of Optometry and Vision Science
• Willingness to not use any ocular lubricants and warm compresses for the duration of the study.
• Willingness to not use eyelid cosmetics at the two visits.

Exclusion Criteria

• Known allergy to hypochlorous acid (All participants will be using 0.02% hypochlorous acid on their eyelids)
• Comorbid ocular surface disease other than dry eye e.g., microbial conjunctivitis, microbial keratitis (Comorbid ocular surface disease states may contribute to ocular signs and symptoms that may confound result findings)
• Ocular surgery or trauma in the last 6 months (Ocular surgery or trauma can introduce bacteria that may confound study results. Hypochlorous acid may affect the bacterial balance of eyes recovering from ocular surgery or trauma)
• Use of contact lenses in the last 4 weeks. (Contact lens use can introduce other bacteria which may confound study results)
• Current use of ocular or systemic medications that may affect ocular microbiota, including antibiotics, immunosuppressants, and steroids. (Some medications may alter tear film physiology which may confound study findings)
• Current use of lid hygiene products such as lid wipes, lid foams and lid sprays with the exception of standard make-up remover that does not contain tea tree oil. (Concurrent use of lid cleaning products would alter normal presence of bacteria and confound the study findings)
• Autoimmune disease or immunosuppressive conditions such as eczema, and psoriasis. (Hypochlorous acid may have potential side effects in people with autoimmune disease due to its effect on bacteria)
• Lactating or pregnant women (The effect of hypochlorous acid on lactating and pregnant women and the foetus are unknown)
• History of migraine or epilepsy exacerbated by flashing lights (exposure to flashing lights during LipiView examination may trigger an episode or attack)

Study & Design

• Study Type: Interventional
• Study Design: Not specified