Epidemiology of Papillomavirus Infection (HPV) on Infected Women by Human Immunodeficience Virus (HIV) in West Indies and French Guiana.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 455
- 试验地点
- 1
- 主要终点
- Presence of human papillomavirus
研究概览
简要总结
Cervical cancer is a public health problem. In term of frequency and mortality, it represents in Martinique the third localization the most frequently diagnosed and the fifth cause of death by cancer. Cervical cancer is recognized as viro-inducted. Human papillomavirus (HPV) is the etiologic agent, as a necessary but not sufficient cause, in the cancer genesis. It is estimated than about 70 to 80% of women have been or will be infected with an HPV in their genital life, the risks factors being those of the others sexually transmitted diseases (STD). Most of HPV infection are transient, by spontaneous clearance in a few months of the virus under episomal form.
Carcinogen risk is related to viral persistency which inducts the condition of cellular transformation.
Infection persistency and subsequent carcinogen risk depend of the genotype concerned and of the host immunitary response.
HIV infection is known to be associated with an higher prevalency of one or several infection with HPV-HR.
However, no data about HIV/HPV coinfection prevalency are available nowadays in French overseas department of South America whereas they are the most affected by HIV.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Women aged 18 years old or beyond
- •Infected with HIV1 or HIV2
- •Follow up for HIV infection in one of the center participating in the study and acceptance of the use of Nadis® medical files
- •in one of the center participating in the study and acceptance of the use of Nadis® medical files within the context of follow up that should be realized according to the recommandation of undertaking: systematic Pap smear for asymptomatic patient s (expert's report, Pr.P.Yéni) or Pap smear for classical searching of any pathology of the uterine-cervix.
- •Acceptance of involvement into the study and collection of non opposition to the realization of HPV search from the sample realized for the Pap smear.
排除标准
- •Women under age
- •History of total hysterectomy
- •Patient not followed for HIV infection in one of the center involved in the study
- •Patient that did not accept the use of Nadis® medical files
- •Impossibility to realize a Pap smear
- •Refusal of study's participation
结局指标
主要结局
Presence of human papillomavirus
时间窗: 1 day
Presence of human papillomavirus in women's cervical smear infected with HIV and followed in West Indies and French Guiana
次要结局
- Characterization of Human papillomavirus genotypes(1 day)
- Presence and the severity of cervical injuries.(1 day)