A Comparative Study To Evaluate The Efficacy Of Intralesional Injections Of Triamcinolone Acetonide Versus Vitamin D3 In The Treatment Of Alopecia Areata
Trial Snapshot
- Phase
- Phase 4
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 72
- Locations
- 1
- Primary Endpoint
- Improvement of SALT Scoring and Digital Photography.
Study Overview
Brief Summary
TITLE - A Comparative study to evaluate the efficacy of Intralesional injections of Triamcinolone acetonide versus Vitamin D3 in the treatment of Alopecia areata
BACKGROUND-
Alopecia areata is an autoimmune condition .Immune system mistakenly attacks hair follicles that leads to patches of non scarring hair loss. Exact cause of alopecia areata is not known and believed to involve a combination of genetic, environmental, and immunological factors. Intralesional Cortiocosteroid affect local cytokine expression leading to gradual decrease in type 1 and 2 cytokines in parallel with clinical improvement suggesting direct suppression of local immune response. Vitamin D receptors (VDRs) highly expressed in keratinocytes of human hair follicles and absence of expression of VDRs associated with reduced hair follicle growth and epidermal differentiation.
MATERIAL AND METHODS - The study was a prospective, randomized, open-labeled investigation conducted over 18 months. It took place at the Department of Pharmacology, in collaboration with the Department of Dermatology, at Era’s Lucknow Medical College and Hospital in Lucknow. The research focused on patients presenting to the Dermatology outpatient department with a clinical diagnosis of alopecia areata. The sample size consisted of 72 patients, divided equally into two groups of 36 each.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Masking
- None
Eligibility Criteria
- Ages
- 18.00 Year(s) to 60.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •Non-scarring, patchy hair loss over the scalp.
- •Patients who have not received any treatment for Alopecia areata in past 4 weeks.
Exclusion Criteria
- •Individuals under 18 years of age.
- •Women who are pregnant and lactating.
- •Patients with local site skin infection.
- •Patients on Immunosuppresants.
- •Patients with underlying malignancies.
- •Patients taking Vitamin D supplements in last 6 months.
Outcomes
Primary Outcomes
Improvement of SALT Scoring and Digital Photography.
Time Frame: 3rd week 6th week 9th week and 12th week
Secondary Outcomes
- Adverse drug reaction(3, 6, 9 and 12th week)
Investigators
Medha Mishra
Eras Lucknow Medical College and Hospital