Effect of Topical Corticosteroids on the Incidence of Postinflammatory Hyperpigmentation Following Q-switched Nd:YAG 532 nm Laser for Treatment of Facial Lentigines - A Pilot Study
Overview
- Phase
- Not Applicable
- Intervention
- topical 0.05% Clobetasol propionate ointment
- Conditions
- Lentigines
- Sponsor
- Mahidol University
- Enrollment
- 21
- Locations
- 1
- Primary Endpoint
- The incidence of post inflammatory hyperpigmentation
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
To investigate the benefit of the application of topical high potency steroid on the incidence of post inflammatory hyperpigmentation after laser treatment.
Detailed Description
* The incidence of post inflammatory hyperpigmentation (PIH) after treating lentigines with Q-switched Nd:YAG laser was 78.3%. * It has been found that the incidence of PIH decreased to 40% after applied topical high potency steroid 2 days after the laser treatment. * By these anti-inflammatory and anti-PIH effects of the high potency steroid, the investigators aimed that the application of steroid 2 days before and 2 days after the laser treatment would be better reduction in the incidence of PIH after Q-switched Nd:YAG laser.
Investigators
Woraphong Manuskiatti, M.D.
Professor
Mahidol University
Eligibility Criteria
Inclusion Criteria
- •Having multiple lentigines on both sides of the face
- •Fitzpatrick skin phototype 3-5
Exclusion Criteria
- •Patients with lesions with any clinical suspicion of being pre-cancerous or skin malignancies of any kind
- •Patients who have photosensitive dermatoses
- •Pregnancy and lactation woman
- •Patients with wound infections (herpes, other) on the day of treatment
- •Patients with moderate and severe inflammatory acne, Immunosuppressed patients, history of vitiligo
- •Patients with unrealistic concerns/expectations and inability to do the appropriate post-operative care
Arms & Interventions
laser+steroid 2 days before and after laser
Before lentigines' treatment with Qs Nd:YAG 532 nm laser, topical 0.05% Clobetasol propionate ointment was applied 2 days on the lesion. Then applied 2 days after the treatment.
Intervention: topical 0.05% Clobetasol propionate ointment
laser+steroid 2 days after laser
Controlled side. Applied topical 0.05% Clobetasol propionate ointment only 2 days after the laser treatment
Intervention: topical 0.05% Clobetasol propionate ointment
Outcomes
Primary Outcomes
The incidence of post inflammatory hyperpigmentation
Time Frame: 2 weeks
By investigator's observation.
Secondary Outcomes
- Side effects of topical steroid(Follow-up 2, 3, 4, 8, 12 and 24 weeks after the last treatment)
- The patients satisfaction(Follow-up 4, 8, 12 and 24 weeks after the last treatment)