Effect of Yoga intervention on progression of Chronic Kidney Disease
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 65
- 试验地点
- 1
- 主要终点
- 25% reduction in Proteinuria
研究概览
简要总结
Chronic kidney disease (CKD) is a global health burden defined as irreversible kidney injury and has repercussions for other organs, leading to many extrarenal complications. Currently, CKD treatment focuses on its complications, hypertension, diabetes. Underlying mechanism driving CKD like oxidative stress, inflammation remain unaddressed. Yoga targets these factors and control blood pressure, diabetes which is crucial to slowdown CKD progression. Yoga modulates gene expression epigenetically, improves fitness, mental health thereby improving QOL. Effects of lifestyle intervention like yoga which target physical, psychological & molecular aspects of body remain explored in CKD. Our study aims to find effect of yoga on CKD progression by assessing clinical, molecular parameters, urinary exosomal miRNA.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Year(s) 至 80.00 Year(s)（—）
- 性别
- All
入选标准
- •CKD stage 3 & 4 patients, Mentally and physically fit up to a level to understand and perform yogic asanas, Not enrolled in regular yoga practice.
排除标准
- •will be HIV, HCV HBsAg +ve patients, individuals with severe cardiovascular conditions active infection, respiratory conditions COPD, neurological disorder and cancer.
结局指标
主要结局
25% reduction in Proteinuria
时间窗: After 3 months of yoga intervention
次要结局
- Stable eGFR (estimated glomerular filtration rate) or increase in eGFR(After 3 months of yoga intervention)
- Reduction in markers of inflammation and oxidative stress post yoga(After 3 months of yoga intervention)
- Markers of CKD metabolic bone disease and kidney injury will toward normal(After 3 months of yoga intervention)
- Reduction in adipokine levels in blood(After 3 months of yoga intervention)
- Expression and methylation pattern of genes involved in CKD will come toward normal(After 3 months of yoga intervention)
- Profibrotic miRNA in urinary exosomes should decrease(After 3 months of yoga intervention)
- Improvement in quality of life(After 3 months of yoga intervention)
研究者
Dr Rima Dada
AIIMS, New Delhi