RELATE and PREDICT TRD.

• Conditions: Major Depressive Disorder

• Registration Number: NL-OMON27079
• Lead Sponsor: MCG

Brief Summary

/A

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 105

Inclusion Criteria

Patients:

1. Male or female, age: 20 - 60 years;

Exclusion Criteria

Patients:

1. Psychotic or Bipolar depression;

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Clinical:<br /><br>1. Decrease in HDRS17-score (continuous scores);<br /><br>2. Response and remission (defined as >=50% decrease in HDRS17 and a HDRS17<=7, respectively);<br /><br>3. Early improvement in week 2 will be defined as >=20% decrease in HDRS.<br><br /><br /><br>Neuroimaging:<br /><br>1. Pavlovian learning paradigm: BOLD response of prediction errors in VTA/ventral striatum/habenula;<br /><br>2. PET: amphetamine challenged decrease in [11C]Raclopride binding in the striatum.