Effect of Probiotic Supplementation on Metabolic Inflammation in Prediabetic Obese Patients in A Tertiary Care Hospital: A Double Blind, Randomized, Placebo Controlled Trial

This MD thesis proposal aims to assess the impact of probiotic supplementation on metabolic inflammation in prediabetic obese patients. The study, with a sample size of 70, will evaluate glycemic control, insulin resistance, oxidative stress, and gut permeability. Participants will be randomized into probiotic and placebo groups, receiving treatment for 12 weeks, with regular follow-ups to monitor compliance and adverse effects. The study’s outcomes may contribute valuable insights to the limited body of randomized control trials on the gut microbiome’s role in prediabetes and obesity.