NCT00442273已完成不适用
Comparison of Autologous Serum and Umbilical Cord Serum Eyedrops for Dry Eye Syndrome
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 试验地点
- 2
研究概览
简要总结
To compare the therapeutic effect between autologous serum and umbilical cord serum eyedrops in the treatment of severe dry eye syndrome.
详细描述
Ninety-two eyes of 48 patients with severe dry eye syndrome (34 eyes of 17 patients with Sjögren's syndrome and 58 eyes of 31 patients with non-Sjögren's syndrome) were treated with either 20% autologous serum (41 eyes of 21 patients) or umbilical cord serum eyedrops (51 eyes of 27 patients). Symptom scoring, corneal sensitivity test, tear film break-up time (BUT), Schirmer test, tear clearance rate (TCR), corneal fluorescein staining, and conjunctival impression cytology were performed before and 1 month and 2 months after treatment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 20 Years 至 61 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with severe dry eye syndrome who were refractory to conventional treatments and had symptoms of dry eye for more than 3 months
- •Low tear film break-up time (BUT, < 5 sec)
- •Low Schirmer test (5 mm)
- •Positive fluorescein or rose bengal vital staining (≥ 3)
排除标准
- •Active ocular infection or inflammation not associated with dry eye
- •Contact lens wear
- •Ocular allergy
- •Ocular surgery within the recent 3 months
- •Lid or lash abnormalities
- •Pregnant or lactating women
研究者
研究点 (2)
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