Comparison of Autologous Serum and Umbilical Cord Serum Eyedrops for Dry Eye Syndrome
Not Applicable
Completed
- Conditions
- Dry Eye Syndrome
- Registration Number
- NCT00442273
- Lead Sponsor
- Chonnam National University Hospital
- Brief Summary
To compare the therapeutic effect between autologous serum and umbilical cord serum eyedrops in the treatment of severe dry eye syndrome.
- Detailed Description
Ninety-two eyes of 48 patients with severe dry eye syndrome (34 eyes of 17 patients with Sjögren's syndrome and 58 eyes of 31 patients with non-Sjögren's syndrome) were treated with either 20% autologous serum (41 eyes of 21 patients) or umbilical cord serum eyedrops (51 eyes of 27 patients). Symptom scoring, corneal sensitivity test, tear film break-up time (BUT), Schirmer test, tear clearance rate (TCR), corneal fluorescein staining, and conjunctival impression cytology were performed before and 1 month and 2 months after treatment.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
- Patients with severe dry eye syndrome who were refractory to conventional treatments and had symptoms of dry eye for more than 3 months
- Low tear film break-up time (BUT, < 5 sec)
- Low Schirmer test (5 mm)
- Positive fluorescein or rose bengal vital staining (≥ 3)
Exclusion Criteria
- Active ocular infection or inflammation not associated with dry eye
- Contact lens wear
- Ocular allergy
- Ocular surgery within the recent 3 months
- Lid or lash abnormalities
- Pregnant or lactating women
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Chonnam national university hospital
🇰🇷Gwangju, Korea, Republic of