Can metformin be safely used in patients with heart failure?

Phase 4

Recruiting

• Conditions: Chronic heart failure; Cardiovascular - Other cardiovascular diseases

• Registration Number: ACTRN12617001418369
• Lead Sponsor: St Vincent's Hospital Sydney

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-10-09
• Last Update Posted: 7 December 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

Study B & C - Patients with heart failure (NYHA Grade I-III, Preserved or Reduced Ejection Fraction)
Patients not currently taking metformin

Study A - Patients with heart failure (NYHA Grade I-III, Preserved or Reduced Ejection Fraction)
Patients currently taking metformin

Exclusion Criteria

Patients who are currently on metformin

Patients who have type II diabetes mellitus (Study B & C Only)

Women lactating, pregnant or of childbearing potential who are not willing to avoid becoming pregnant during the study.

Patients with a history of a psychological illness or condition such as to interfere with the patient's ability to understand the requirements of the study.

Patients with a history of lactic acidosis.

Patients with grade IV heart failure

Patients with chronic kidney disease ( creatinine clearance < 30 ml/min)

Study & Design

• Study Type: Interventional
• Study Design: Not specified