Predicting Lung Injury From Transfusion in Patients With Liver Disease

Terminated

• Conditions: Transfusion-related Acute Lung Injury; Gastrointestinal Bleeding; Chronic Liver Disease

• Registration Number: NCT01756690
• Lead Sponsor: University of Colorado, Denver

Brief Summary

A certain molecule floating in the blood may represent a risk of lung injury after a transfusion. We are determining whether detection of this molecule on a simple blood clotting test will predict the development of lung injury due to transfusion in bleeding patients with chronic liver disease.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-10
• Study First Submitted: 2012-12-20
• Study First Submitted QC: 2012-12-20
• Study First Posted: 2012-12-27
• Primary Completion: 2014-10
• Study Completion: 2016-12
• Status Verified: 2017-01
• Last Update Submitted: 2017-01-27
• Last Update Posted: 2017-01-30

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

Not provided

Read More

Exclusion Criteria

Not provided

Read More

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
TRALI (consensus definition- with exception of absence of other acute lung injury risk factors)	0-54 hours post enrollment

Secondary Outcome Measures

Name	Time	Method
Bleeding complications	0-5 days post-enrollmnet	Baveno V criteria
Change in ratio of partial pressure of oxygen to fraction of inspired oxygen (PaO2/FiO2)	0-54 hours post enrollment

Trial Locations

Locations (2)

University of Colorado Denver, Anshutz medical campus; 🇺🇸 Aurora, Colorado, United States

Denver Health and Hospital; 🇺🇸 Denver, Colorado, United States