Discontinuation of Inhaled Steroid in Controlled asthmatics Over 6 months (DISCO) study

Asan Medical Center0 个研究点目标入组 200 人开始时间: 待定最近更新: 2019年3月11日

适应症

试验速览

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•1) aged over 18 years 2) physician-diagnosed asthma 3) an evidence of reversible airway obstruction with positive bronchodilator response [>12% improvement in percentage of forced expiratory volume in 1 sec(FEV1) and at least 200 ml after inhalation of 180 mg of albuterol] or an airway hyper-responsiveness with positive methacholine bronchial provocation test [provocative concentration of methacholine causing a 20% reduction in FEV1=16 mg/mL] or FEV1 variability of greater than 15% during outpatient visit and 4) FEV1 greater than 70% of expected value.

•Exclusion criteria included any of followings; cigarette smoking more than 10 pack-years, history of pulmonary tuberculosis with aftereffect, bronchiectasis or emphysema in chest X-ray, patients who are about to start immunotherapy and who take any kind of immunomodulatory like systemic corticosteroid, leukotriene modifier, theophylline and tiotropium.

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