Cerebral and Peripheral Electrical Stimulation on Isometric Quadriceps Strength

Phase 2

Completed

• Conditions: Healthy Volunteers
• Interventions: Device: Cerebral stimulation; Device: Peripheral stimulation

• Registration Number: NCT03870139
• Lead Sponsor: Universidade Federal do Piauí

Brief Summary

Quadriceps muscle strength is a key goal to be achieved in rehabilitation protocols for a variety of musculoskeletal conditions. Both cerebral and peripheral electrical stimulations can modulate motor brain areas involved in motor functions and has the potential to optimize muscle capacity. However, their effects on quadriceps function are lacking.

This study aims to investigate the effects of transcranial direct current stimulation (tDCS) and peripheral electrical stimulation (PES) on quadriceps strength in healthy subjects.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-03-08
• Study First Submitted QC: 2019-03-08
• Study First Posted: 2019-03-11
• Study Start: 2019-03-30
• Primary Completion: 2019-04-30
• Status Verified: 2019-05
• Study Completion: 2019-05-07
• Last Update Submitted: 2019-05-07
• Last Update Posted: 2019-05-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Healthy subjects with no complaints of pain, discomfort in the musculoskeletal system.

Exclusion Criteria

• Musculoskeletal or neurological disorder
• Under medication

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Combined stimulation 1	Cerebral stimulation	Active peripheral electrical stimulation (PES_sensorial) combined with active transcranial direct current stimulation tDCS: 20 minutes, 2mA, primary motor cortex anode (contralateral to the lesion) and supraorbital cathode (ipsilateral to the lesion). PES_sensorial: 20 minutes, 10Hz (frequency), 100µs (pulse duration), intensity at sensorial level.
Combined stimulation 1	Peripheral stimulation	Active peripheral electrical stimulation (PES_sensorial) combined with active transcranial direct current stimulation tDCS: 20 minutes, 2mA, primary motor cortex anode (contralateral to the lesion) and supraorbital cathode (ipsilateral to the lesion). PES_sensorial: 20 minutes, 10Hz (frequency), 100µs (pulse duration), intensity at sensorial level.
Combined stimulation 2	Peripheral stimulation	Active sensorial peripheral electrical stimulation (PES_sensorial) combined with active motor peripheral electrical stimulation (PES_motor) PES_sensorial: 20 minutes, 10Hz (frequency), 100µs (pulse duration), intensity at sensorial level PES_motor: 15 minutes, 30Hz (frequency), 100µs (pulse duration), intensity at motor level.
Cerebral stimulation	Cerebral stimulation	Active transcranial direct current stimulation tDCS: 20 minutes, 2mA, primary motor cortex anode (contralateral to the dominant lower limb) and supraorbital cathode (ipsilateral to the dominant lower limb).
Combined stimulation 2	Cerebral stimulation	Active sensorial peripheral electrical stimulation (PES_sensorial) combined with active motor peripheral electrical stimulation (PES_motor) PES_sensorial: 20 minutes, 10Hz (frequency), 100µs (pulse duration), intensity at sensorial level PES_motor: 15 minutes, 30Hz (frequency), 100µs (pulse duration), intensity at motor level.
Peripheral stimulation	Peripheral stimulation	Active peripheral electrical stimulation (PES_motor). PES: 15 minutes, 30Hz (frequency), 100µs (pulse duration), intensity at motor level.

Primary Outcome Measures

Name	Time	Method
Isometric quadriceps strength	Pre and Post-test (immediately after tDCS)	Maximal isometric voluntary contraction (Kgf)

Secondary Outcome Measures

Name	Time	Method
Isometric quadriceps strength	10 minutes post-stimulation	Maximal isometric voluntary contraction (Kgf)

Trial Locations

Locations (1)

Department of Physical Therapy. Federal University of Piaui; 🇧🇷 Parnaíba, Piauí, Brazil