Increased incidence of type 2 diabetes and cardiovascular disease in Hindostani as compared to Caucasians: role of intracellular pathways leading to glucose uptake and mitochondrial function on ectopic fat storage. - Pathofysiology of type 2 diabetes and CVD in Hindostani versus Caucasians

eids Universitair Medisch Centrum0 个研究点目标入组 72 人开始时间: 待定最近更新: 2024年5月6日

适应症

试验速览

暂无简介。

•Young men (2x12):
•- Male healthy volunteers, 12 Hindostani and 12 Caucasians, born in the Netherlands
•- Age > 18 years and <= 25 years
•- BMI > 20 kg/m2 and < 25 kg/m2
•- 1 parent or grandparent with DM2 and >= 1 other relative;Middle-aged men (2x12):
•- Male volunteers, 12 Hindostani and 12 Caucasians, born in the Netherlands
•- Age 40-50 years
•- Waist circumference > 94cm for Caucasians and > 90 cm for Hindostani
•- BMI > 27 and < 35 kg/m2
•- 1 parent or grandparent with DM2 and >= 1 other relative;Study 2.
•- Male healthy volunteers, 12 Hindostani and 12 Caucasians, born in the Netherlands
•- Age >= 18 years and <= 25 years
•- BMI >= 20 kg/m2 and <= 25 kg/m2
•- 1 parent or grandparent with DM2 and >= 1 other relative;Study 3:
•Participation to study 1 (main study)

•- Diabetes mellitus as defined by ADA criteria {2008 39 /id}
•- Any significant chronic disease
•- Renal, hepatic or endocrine disease
•- Cardiovascular disease, including complaints of angina pectoris or intermittend claudicatio
•- Use of medication known to influence glucose and/or FFA metabolism
•- Recent weight changes or attempts to loose weight (> 3 kg weight gain or loss, within the last 3 months)
•- Difficulties to insert an intravenous catheter
•- Severe claustrophobia (ventilated hood, MRI)
•- Contra-indications for the MRI (pacemakers, internal defibrillator, clips etc)
•- Recent blood donation (within the last 3 months)
•- Recent participation in other research projects (within the last 3 months), participation in 2 or more projects in one year

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