NL-OMON38272
Recruiting
Not Applicable
Increased incidence of type 2 diabetes and cardiovascular disease in Hindostani as compared to Caucasians: role of intracellular pathways leading to glucose uptake and mitochondrial function on ectopic fat storage. - Pathofysiology of type 2 diabetes and CVD in Hindostani versus Caucasians
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- insulin resistance
- Sponsor
- eids Universitair Medisch Centrum
- Enrollment
- 72
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Young men (2x12\):
- •\- Male healthy volunteers, 12 Hindostani and 12 Caucasians, born in the Netherlands
- •\- Age \> 18 years and \<\= 25 years
- •\- BMI \> 20 kg/m2 and \< 25 kg/m2
- •\- 1 parent or grandparent with DM2 and \>\= 1 other relative;Middle\-aged men (2x12\):
- •\- Male volunteers, 12 Hindostani and 12 Caucasians, born in the Netherlands
- •\- Age 40\-50 years
- •\- Waist circumference \> 94cm for Caucasians and \> 90 cm for Hindostani
- •\- BMI \> 27 and \< 35 kg/m2
- •\- 1 parent or grandparent with DM2 and \>\= 1 other relative;Study 2\.
Exclusion Criteria
- •\- Diabetes mellitus as defined by ADA criteria {2008 39 /id}
- •\- Any significant chronic disease
- •\- Renal, hepatic or endocrine disease
- •\- Cardiovascular disease, including complaints of angina pectoris or intermittend claudicatio
- •\- Use of medication known to influence glucose and/or FFA metabolism
- •\- Recent weight changes or attempts to loose weight (\> 3 kg weight gain or loss, within the last 3 months)
- •\- Difficulties to insert an intravenous catheter
- •\- Severe claustrophobia (ventilated hood, MRI)
- •\- Contra\-indications for the MRI (pacemakers, internal defibrillator, clips etc)
- •\- Recent blood donation (within the last 3 months)
Outcomes
Primary Outcomes
Not specified
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