Increased incidence of type 2 diabetes and cardiovascular disease in Hindostani as compared to Caucasians: role of intracellular pathways leading to glucose uptake and mitochondrial function on ectopic fat storage.

Recruiting

Conditions: insulin resistance
sugar disease
10018424

Registration Number: NL-OMON38272

Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 72

Inclusion Criteria

Study 1
Young men (2x12):
- Male healthy volunteers, 12 Hindostani and 12 Caucasians, born in the Netherlands
- Age > 18 years and <= 25 years
- BMI > 20 kg/m2 and < 25 kg/m2
- 1 parent or grandparent with DM2 and >= 1 other relative;Middle-aged men (2x12):
- Male volunteers, 12 Hindostani and 12 Caucasians, born in the Netherlands
- Age 40-50 years
- Waist circumference > 94cm for Caucasians and > 90 cm for Hindostani
- BMI > 27 and < 35 kg/m2
- 1 parent or grandparent with DM2 and >= 1 other relative;Study 2.
- Male healthy volunteers, 12 Hindostani and 12 Caucasians, born in the Netherlands
- Age >= 18 years and <= 25 years
- BMI >= 20 kg/m2 and <= 25 kg/m2
- 1 parent or grandparent with DM2 and >= 1 other relative;Study 3:
Participation to study 1 (main study)

Exclusion Criteria

- Diabetes mellitus as defined by ADA criteria {2008 39 /id}
- Any significant chronic disease
- Renal, hepatic or endocrine disease
- Cardiovascular disease, including complaints of angina pectoris or intermittend claudicatio
- Smoking
- Use of medication known to influence glucose and/or FFA metabolism
- Recent weight changes or attempts to loose weight (> 3 kg weight gain or loss, within the last 3 months)
- Difficulties to insert an intravenous catheter
- Severe claustrophobia (ventilated hood, MRI)
- Contra-indications for the MRI (pacemakers, internal defibrillator, clips etc)
- Recent blood donation (within the last 3 months)
- Recent participation in other research projects (within the last 3 months), participation in 2 or more projects in one year