Efficacy of Rectal Indomethacin in Prevention of Post-pancreatectomy Acute Pancreatitis-A Randomized Controlled Trial
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 200
- 主要终点
- Post-pancreatectomy Acute Pancreatitis
研究概览
简要总结
The purpose of this study is to evaluate the efficacy of rectal indomethacin in prevention of post-pancreatectomy acute pancreatitis.
详细描述
The purpose of this study is to evaluate the efficacy of rectal indomethacin in prevention of post-pancreatectomy acute pancreatitis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •*All patients planned to undergo pancreatectomy.
排除标准
- •allergic reactions to NSAIDs
- •internal hemorrhoids
- •anti-platelet medications
研究组 & 干预措施
Group A
Patients will be administered 100mg of Indomethacin Suppository sigle dose at the time of induction of anesthesia with Standard Medical Treatment
干预措施: Indomethacin suppository (Drug)
Group A
Patients will be administered 100mg of Indomethacin Suppository sigle dose at the time of induction of anesthesia with Standard Medical Treatment
干预措施: Standard Medical Treatment (Other)
Group B
Standard Medical Treatment
干预措施: Standard Medical Treatment (Other)
结局指标
主要结局
Post-pancreatectomy Acute Pancreatitis
时间窗: 2 weeks after pancreatectomy
次要结局
- Peripancreatic abscess(30 days after pancreatectomy)
- Length of hospital stay(30 days after pancreatectomy)
- Pancreatic Fistula(30 days after pancreatectomy)
研究者
Yingbin Liu, MD, PhD, FACS
prof.
Shanghai Jiao Tong University School of Medicine