Neutrophil Phenotypic Profiling and Surgical Site Infections in Surgical Patients
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 220
- 试验地点
- 1
- 主要终点
- Neutrophil populations
研究概览
简要总结
Surgical site infections (SSIs) are one of the major hospital acquired infections and responsible for the most cost among the hospital acquired infections. The objective of this study is to assess the neutrophil functional profiles and their associations with SSIs.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 12 Months 至 19 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •scheduled for an elective open gastrointestinal surgical procedure or spine fusion surgery
排除标准
- •On chronic immunosuppressive drugs such as chronic corticosteroid use
- •preexisting immunodeficiency diseases
研究组 & 干预措施
Spine Surgery
Pediatric patients presenting for elective spine fusion surgery at Boston Children's Hospital
干预措施: Surgical Site Infection (Other)
Abdominal Surgery
Pediatric patients presenting for elective abdominal surgery at Boston Children's Hospital
干预措施: Surgical Site Infection (Other)
结局指标
主要结局
Neutrophil populations
时间窗: up to 3 days
compare neutrophil population between patients with SSI and without SSI by delineating transcriptomic profiles
Neutrophil functional impairment
时间窗: up to 3 days
illustrate neutrophil subpopulation associated with neutrophil functional impairment and SSIs by probing phagocytosis and reactive oxygen species formation
次要结局
未报告次要终点
研究者
Koichi Yuki
Principal Investigator
Boston Children's Hospital