Vitamin D Levels and Risk of Infection, Assessment for Disease Severity, and Predictor of Mortality in the Chinese Intensive Care Units: a Prospective Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 234
- 试验地点
- 1
- 主要终点
- Patients Outcome
研究概览
简要总结
The higher rate of vitamin D deficiency is spotted among patients being hospitalized or in critical condition. Especially, vitamin D level below normal prolongs hospital stay and increases incidence of adverse prognosis and pushing up mortality of a number of diseases. However, it is remain unclear the relationship between vitamin D levels and critically ill, especially infection or sepsis. In this study, the investigators evaluate the significance of vitamin D for diagnosis and other relevant assessments of ICU cases, including vitamin D's relevance to sepsis, as well as its value in severity and prognosis assessment, high-performance liquid chromatography and tandem mass spectrometry was used to detect the quantification of the total 25(OH)D in serum of critically ill patients. The investigators speculate that measurement of vitamin D could be taken as an indicator for diagnosis and assessment in critically ill patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male and female aged 18 years old and over;
- •Entered ICU;
- •Fulfilled at least two criteria of systemic inflammatory response syndrome
- •core temperature higher than 38 °C or lower than 36 °C
- •respiratory rate above 20/min, or PCO2 below 32 mmHg
- •pulse rate above 90/min, and
- •white blood cell count greater than 12,000/μl or lower than < 4,000/μl or less than 10% of bands.
排除标准
- •patients or their relatives refused
结局指标
主要结局
Patients Outcome
时间窗: 90 days
The survival time of patients more than 90 days is defined as survival. The survival time of patients less than 90 days is defined as death.
次要结局
未报告次要终点
研究者
Longxiang Su
Dr.
Chinese PLA General Hospital