Effect of CPAP Therapy on LPR Among Patients With OSAS
- Conditions
- Obstructive Sleep ApneaLaryngopharyngeal Reflux
- Registration Number
- NCT03455803
- Lead Sponsor
- Assiut University
- Brief Summary
This study will investigate the changes in the reflux symptom index (RSI) and reflux finding score (RFS) among patients with obstructive sleep apnea after regular humidified CPAP therapy. Since these two diseases have strong associations then one may consider the possible benefits from therapy in between them.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
- Patients have to stop proton pump inhibitors (PPI) therapy 1 month before enrollment in the study.
- To be eligible as LPR patients in our study, patients must have presented a RSI score > 13 and a RFS score > 7. These thresholds were highly correlated with pathological pH monitoring (pH < 4)
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Exclusion Criteria
- Noncompliance for CPAP Use: According to the standard Medicare criteria to define CPAP compliance, the patients who demonstrated CPAP use ≥ 4 h/ night for ≥ 70% of the nights are considered compliant.
- Antireflux therapy during the period of the study.
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Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Reflux symptom index (RSI) change Change from the baseline RSI at 3 months of regular humidified CPAP application Assessment of the changes in the reflux symptom index (RSI) among patients with obstructive sleep apnea according to the determined time frame
Reflux finding score (RFS) change Change from the baseline RFS at 3 months of regular humidified CPAP application Assessment of the changes in the reflux finding score (RFS) among patients with obstructive sleep apnea according to the determined time frame
- Secondary Outcome Measures
Name Time Method