Impact of Skeletal Muscle Quality and Loss on the Outcome of Liver Transplantation
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 800
- 主要终点
- Postoperative recurrence of liver cancer
研究概览
简要总结
CT imaging-based skeletal muscle assessment has been found to predict the outcomes of many diseases. Previous evidence revealed that pre-transplant muscle quality and post-transplant muscle loss were associated with transplant outcomes. However, there is no prospective study supporting the aforementioned conclusions. This study aims to prospectively include liver transplant patients from multiple transplant centers, collecting their pre-transplant CT images as well as post-transplant CT images at specific time points. The objective is to further explore and clarify the correlation between skeletal muscle assessment and the prognosis of liver transplant patients. The goal is to provide guidance for peri-transplant health monitoring and disease intervention for liver transplant patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients undergoing deceased donor liver transplantation (DDLT) for the first time
排除标准
- •Pediatric transplants
- •Presence of portal vein tumor thrombus according to imageing before transplantation
- •Presence of macrovascular invasion according to imageing before transplantation
- •Re-transplants
- •Multi-organ transplants
- •Patients who died within 30 days after transplantation
- •Patients diagnosed with skeletal muscle diseases (e.g. muscle atrophy)
- •Patients with serious medical conditions such as heart failure, persistent infection, and renal insufficiency.
结局指标
主要结局
Postoperative recurrence of liver cancer
时间窗: 2024.1.1-2027.1.1
Specifically for the included patients who undergo liver transplantation for liver cancer
Postoperative mortality
时间窗: 2024.1.1-2027.1.1
次要结局
未报告次要终点
研究者
Xiao Xu
Professor
Zhejiang University