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Sympathetic Nerve Activation Evoked by Diesel Exhaust Exposure

Not Applicable
Completed
Conditions
Healthy
Registration Number
NCT02892279
Lead Sponsor
Umeå University
Brief Summary

The adverse effects of air pollution on cardiovascular and respiratory health have been demonstrated in an extensive series of epidemiological, observational and experimental studies. In the current project the investigators aim to determine whether an acute exposure to diesel exhaust causes impacts on sympathetic nervous system activation in healthy volunteers.

Detailed Description

Brief as well as chronic exposures to air pollution have been linked with increases in cardiovascular morbidity and mortality. Evidence suggests that the strongest associations between air pollution exposure and adverse cardiovascular effects are found for combustion-derived particulate matter, especially in the fine and ultrafine ranges such as is found in diesel engine emissions. Despite a greater understanding of the cardiovascular effects of air pollution, the underlying mechanism through which exposure to fine particulate air pollution alters vascular function has yet to be determined. Microneurography is a method that records nerve impulse traffic in human peripheral nerves, allowing for the assessment of sympathetic nervous activity. The current study will employed microneurography techniques to evaluate autonomic function in association with inhaled air pollution exposure in healthy human volunteers.

Recruitment & Eligibility

Status
COMPLETED
Sex
Male
Target Recruitment
15
Inclusion Criteria
  • Healthy (normal ECG, lung function, blood sample, clinical examination)
Exclusion Criteria
  • Metabolic disease
  • Cardiovascular disease
  • Respiratory disease
  • BMI ≥ 30
  • Use of psychoactive medication
  • Infection within 2 weeks of the study
  • Smokers or regular snus usage

Study & Design

Study Type
INTERVENTIONAL
Study Design
SINGLE_GROUP
Primary Outcome Measures
NameTimeMethod
Microneurography1 hour

Microneurography recording of muscle sympathetic nervous system activity

Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (1)

Dept of Medicine, Lung and Allergy section, University Hospital

🇸🇪

Umeå, Sweden

Dept of Medicine, Lung and Allergy section, University Hospital
🇸🇪Umeå, Sweden

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