Acute Haemodynamic Study of TPN171H in Patients with Pulmonary Arterial Hypertension
- Conditions
- Pulmonary Arterial Hypertension
- Interventions
- Registration Number
- NCT04483115
- Lead Sponsor
- Vigonvita Life Sciences
- Brief Summary
This study is a phase IIa proof-of-concept study to evaluate the effect of single-dose TPN171H tablets on acute haemodynamic parameters in patients with pulmonary arterial hypertension.The trial is expected to include 60 patients, divided into 6 groups, according to 1:1:1:1:1:1 into the placebo group and the test drugs 2.5mg, 5mg, 10mg group, tadalafil tablets 20mg, 40mg group, each group 10 cases.
- Detailed Description
This study is a multi-center, randomized, placebo and positive controlled phase IIa proof-of-concept study to evaluate the effect of single-dose TPN171H tablets on acute hemodynamic parameters in patients with pulmonary arterial hypertension.The trial is expected to include 60 patients, divided into 6 groups, according to 1:1:1:1:1:1 into the placebo group and the test drugs 2.5mg, 5mg, 10mg group, tadalafil tablets 20mg, 40mg group, each group 10 cases. During the screening period, the tube placement period, and the observation period, the patients will conduct various inspections and evaluation observations as required.
The Swan-Ganz floating catheter and echocardiography were used to evaluate the efficacy of TPN171H; PK parameters: including Tmax, Cmax, AUC0-t , t1/2,CL/F, Vz/F, λz; Safety evaluation indicators include: vital signs, physical examination, laboratory examination (blood routine, blood biochemistry, blood gas analysis), 12-lead ECG, adverse events.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
-
Patients aged 18 to 75;
-
Patients who have voluntarily decided to participate in this study, and signed the informed consent form;
-
Patients who are able to understand and follow study plans and instructions;
-
Patients with symtomatic PAH (Group1), a pulmonary vascular resistance (PVR) > 3 Wood, a mean pulmonary artery pressure (mPVP) ≥25 mmHg and a pulmonary artery wedge pressure (PAWP) ≤ 15 mmHg either due to:
- Idiopathic PAH (IPAH)
- Familial PAH
- Associated PAH due to drugs or toxins
- Associated PAH due to connective tissue disease
- Associated PAH due to congenital heart disease, if patients underwent surgical correction more than 1 year prior to screening
-
Have a current diagnosis of being in WHO functional class II or III;
-
Patients who are willing to take proper contraceptive during the study and within 3 months after the study completed.
- All types of PH except subtypes of Group1 specified in the inclusion criteria;
- Moderate to severe COPD (FEV1 < 60% predicted);
- Moderate to severe restrictive lung disease (FVC < 70% predicted);
- Pre-treatment with PAH therapy within the last 1 months before the screening visit (including endothelin receptor antagonists, PDE5 inhibitors, guanylate cyclase agonist and prostacycline analogues);
- A "positive" response to acute vasodilator testing;
- Coagulation dysfunction (defined as activated partial thromboplastin time and international normalized ratio are both >1.5 times upper limit normal) or patients with potential bleeding risk;
- Hepatic dysfunction indicated by: serum bilirubin>3 times upper limit normal, ALT and AST>2.5 times upper limit normal;
- Renal insufficiency (creatinine clearance<30 mL/min)；
- Systolic blood pressure<90 mmHg at screening;
- QT prolongation at screening, whose values (QTcF) exceeding 450 msec in males and 470 msec in females;
- Have enrolled in/or have a plan of an exercise training program for pulmonary rehabilitation before the screening visit/or during the study;
- Patients who have a recent (within 3 months) history of abusing alcohol or illicit drugs;
- Body weight<40 kg；
- Patients who have participated in a clinical study involving another investigational drug within 1 month before the screening visit;
- For any other reasons that affect compliance with the study protocol, especially the long-term monitoring of floating catheters, according to the decision of investigators;
- HBV, HCV, HIV or Tp infection;
- Patients with gastrointestinal, urinary, reproductive, immunologic, endocrine, or central nervous system disease that, in the opinion of the investigator, will affect the study;
- Have a history of malignancies within 2 years, except for a cured basal cell or skin squamous cell carcinoma;
- Pregnant women, or breast feeding women;
- Patients with hypersensitivity to iloprost or any of the excipients.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description TPN171H 2.5mg group TPN171H TPN171H 2.5mg tablet + Placebo 10mg tablet Placebo group Placebo Placebo 5mg tablet+ Placebo 10mg tablet tadalafil 40mg group Tadalafil tadalafil tablets 20mg \*2 TPN171H 5mg group TPN171H TPN171H 5mg tablet + Placebo 10mg tablet TPN171H 10mg group TPN171H TPN171H 10mg tablet + Placebo 5mg tablet tadalafil 20mg group Tadalafil tadalafil tablet 20mg
- Primary Outcome Measures
Name Time Method Percentage of the maximum change in pulmonary vascular resistance(PVR) to the second baseline Within 24 hours after drug administration
- Secondary Outcome Measures
Name Time Method Time of maximum change in PVR Within 24 hours after drug administration The area under the curve for reduction in PVR Within 24 hours after drug administration Change in arterial oxygenation Within 24 hours after drug administration Change in right ventricular function Within 24 hours after drug administration
Trial Locations
- Locations (9)
Peking Union Medical College Hospital
🇨🇳Beijing, Beijing, China
Fuwai Hospital CAMS&PUMC
🇨🇳Beijing, Beijing, China
Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science & Technology
🇨🇳Wuhan, Hubei, China
The Second Xiangya Hospital of Central South University
🇨🇳Changsha, Hunan, China
First Affiliated Hospital Of Gannan Medical University
🇨🇳Ganzhou, Jiangxi, China
Shanghai Pulmonary Hospital
🇨🇳Shanghai, Shanghai, China
Gansu Provincial Hospital
🇨🇳Lanzhou, Gansu, China
The First Affiliated Hospital of Chongqing Medical University
🇨🇳Chongqing, Chongqing, China
Peking University First Hospital
🇨🇳Beijing, Beijing, China