Comparing Dexamethasone to placebo for treating severe pneumonia in children a clinical trial
Phase 4
- Conditions
- Health Condition 1: J17- Pneumonia in diseases classified elsewhere
- Registration Number
- CTRI/2024/07/071438
- Lead Sponsor
- Siddannagoud salotagi
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. Children with severe community-acquired pneumonia
Exclusion Criteria
1. Child already on steroid therapy ( Any condition requiring 20 mg of prednisone equivalent/day or more for greater than 14 days over the last 3 months)
2. Known Immunodeficiency
3. Comorbidities Comorbidities: Cystic fibrosis, malignancy
4. Presence of pre-existing medical condition that is irreversible and expected to be fatal within 3 months
5. GI bleeding requiring transfusion or requiring withholding of feed for more than 24 hours
6. Active tuberculosis
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method All-cause mortality at 28 daysTimepoint: All-cause mortality at 28 days
- Secondary Outcome Measures
Name Time Method All-cause mortality at day 90 <br/ ><br>Timepoint: 90 days;Duration of ICU hospitalization, and hospital stayTimepoint: total length of stay;Duration of mechanical ventilationTimepoint: Total duration of mechanical ventilation;Duration of oxygen supportTimepoint: Total Duration of oxygen support;New onset HAI during hospitalizationTimepoint: IPD days;Rates of septic shock, and hyperferritinemia, by day 28Timepoint: 28 days