Comparing anti-hypertensive combination therapy of fixed dose losartan and hydrochlorothiazide(HCTZ) versus angiotensin receptor blocker(ARB) and calcium channel blocker(CCB) on hypertensive patients whose blood pressures don't lower enough,effect and influence of metabolic system trial.
- Conditions
- Hypertension
- Registration Number
- JPRN-UMIN000001692
- Lead Sponsor
- Hypertension and Metabolism Study group in East Saitama
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 300
Not provided
1)Patients with uncontrolled diabetes (HbA1c more than 9.0%) 2) Patients with secondary hypertension 3)Patients who have stroke, AMI and/or other critical vascular complications that required hospitalization within 24 weeks prior to the intervention 4)Patients with liver dysfunction [GPT(ALT) over three times the normal value] 5)Patients with renal failure (serum creatinine more than 2.0 mg/dL) 6)Patients with uncontrolled hyperuricemia (more than 9.0mg/dL) 7)Patients with cardiac insufficiency (more than NYHA grade III) 8) Patients with severe malignant cancer or other unfavorable prognostic factors 9)Pregnant or possible pregnant women 10)Patients with a history of hypersensitivity to ingredients of losartan potassium or hydrochlorothiazide 11)Patients with a history of hypersensitivity to thiazide or thiazide-like diuretics 12)Patients who are considered not eligible for the study by the attending doctor due to medical reasons
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changes in blood pressure after 8 weeks. The achievement rate of the blood pressure target level(JSH criteria)after 8 weeks
- Secondary Outcome Measures
Name Time Method Inhibitory effect of development of diabetes. The rate of new-onset diabetes. Change in blood pressure,blood glucose,HbA1c,high-molecular weight adiponectin,hs-CRP,BNP,urinary microalbuminuria. Safty