ISRCTN15622505
Unknown
未知
Children’s Oxygen Administration Strategies Trial (COAST): a randomised controlled trial of high flow versus oxygen versus control in African children with severe pneumonia
Imperial College, London (UK)0 sites1,852 target enrollmentFebruary 20, 2016
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Imperial College, London (UK)
- Enrollment
- 1852
- Last Updated
- 4 years ago
Overview
Brief Summary
2018 Protocol article in https://pubmed.ncbi.nlm.nih.gov/29383331/ protocol
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Aged between 28 days to 12 years
- •2\. History of respiratory illness (cough, upper respiratory tract symptom or any respiratory symptoms, e.g. rapid breathing or increase work of breathing)
- •3\. Hypoxia (pulse oximetry reading of SaO2 \<92% recorded in room air over 5 minutes)
- •4\. Plus any one of the following signs of severe pneumonia (from 2013 WHO clinical definitions for pneumonia):
- •4\.1\.Sign of respiratory distress (any one of):
- •4\.1\.1\. Severe lower chest wall in\-drawing
- •4\.1\.2\. Use of auxiliary muscles
- •4\.1\.3\. Head nodding
- •4\.1\.4\. Inability to feed because of respiratory problems
- •4\.2\. Suspected pneumonia
Exclusion Criteria
- •1\. Known uncorrected cyanotic heart disease
- •2\. Assent/consent refusal by parent/carer
- •3\. Previously recruited to COAST
- •4\. Already received oxygen for this episode of illness
Outcomes
Primary Outcomes
Not specified
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