Children’s Oxygen Administration Strategies Trial (COAST): a randomised controlled trial of high flow versus oxygen versus control in African children with severe pneumonia

Imperial College, London (UK)0 个研究点目标入组 1,852 人开始时间: 2016年2月20日最近更新: 2021年7月21日

研究概览

•1. Aged between 28 days to 12 years
•2. History of respiratory illness (cough, upper respiratory tract symptom or any respiratory symptoms, e.g. rapid breathing or increase work of breathing)
•3. Hypoxia (pulse oximetry reading of SaO2 <92% recorded in room air over 5 minutes)
•4. Plus any one of the following signs of severe pneumonia (from 2013 WHO clinical definitions for pneumonia):
•4.1.Sign of respiratory distress (any one of):
•4.1.1. Severe lower chest wall in-drawing
•4.1.2. Use of auxiliary muscles
•4.1.3. Head nodding
•4.1.4. Inability to feed because of respiratory problems
•4.2. Suspected pneumonia
•4.2.1. Fast breathing:
•4.2.1.1. Age 2–11 months: = 50/minute
•4.2.1.2. Age 1–5 years: = 40/minute
•4.2.1.3. Age 5-12 years = 30/minute
•4.2.2. Chest auscultation signs:
•4.2.2.1. Decreased breath sounds
•4.2.2.2. Bronchial breath sounds
•4.2.2.3. Crackles
•4.2.2.4. Abnormal vocal resonance (decreased over a pleural effusion or empyema, increased over lobar consolidation)
•4.2.2.5. Pleural rub
•4.3. Signs of pneumonia with a general danger sign:
•4.3.1. Inability to breastfeed or drink
•4.3.2. Lethargy or unconscious
•4.3.3. Convulsions

发起方

Imperial College, London (UK)