NL-OMON47003已完成不适用
Synovial Tissue characteristics in Rheumatoid Arthritis patients TreAted with their FIrst Tnf-inhibitor - STRATAFIT
niversitair Medisch Centrum Utrecht0 个研究点目标入组 50 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 50
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •* Age * 18 years
- •* Fulfilling 2010 American College of Rheumatology (ACR) / European League Against Rheumatism (EULAR) classification criteria for RA (Appendix A).
- •* DAS28 * 3.2
- •* At least one clinically active wrist or knee or MCP joint
- •* Start with aTNFi (all currently approved TNFi are allowed* infliximab (3 mg/kg at week 0, 2, 6 and 14), etanercept, adalimumab, golimumab, certolizumab pegol) within 4 weeks from the baseline study visit.
- •* Having insufficient response to treatment with * 2 conventional DMARDs.
- •* Current treatment with either methotrexate (*10 mg/week), sulfasalazine (*2000 mg/day), hydroxychloroquine (*200 mg/day), and/or leflunomide (*10 mg/day).
- •* Naïve to previous biological treatment regimens, including other TNFi, rituximab, abatacept, tocilizumab (and biosimilar equivalents).
排除标准
- •* Treatment with systemic glucocorticoids at a dose above 10 mg/day of prednisone or equivalent within 4 weeks of enrolment.
- •* Treatment with intra-articular glucocorticoids in a knee or wrist or MCP joint within 3 months of enrolment.
- •* Any rheumatic disease other than RA (except secondary Sjogren*s syndrome)
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