Mathematical Model for the Human Menstrual Cycle, Endocrinological Diseases and Fertility Treatment-PAEON

Completed

• Conditions: Hyperprolactinemia; Endometriosis; Polycystic Ovary Syndrome
• Interventions: Other: Fertility treatment

• Registration Number: NCT02098668
• Lead Sponsor: University of Zurich

Brief Summary

Development of a bio-mathematical model of the human female cycle

Detailed Description

From hormonal measurements throughout 1-2 menstrual cycles in women with and without endocrinological pathology a mathematical model of the human menstrual cycle will be generated. The model will serve to predict development of the cycle including ovulation as well as to better understand the pathophysiology of endocrinological disorder. In a second step current treatment protocols for fertility treatment will be integrated into the model in order to optimize treatment outcome.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2013-06-18
• Study Start: 2013-09
• Study First Submitted QC: 2014-03-25
• Study First Posted: 2014-03-28
• Primary Completion: 2016-02
• Study Completion: 2016-04
• Status Verified: 2016-09
• Last Update Submitted: 2016-09-06
• Last Update Posted: 2016-09-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 123

Inclusion Criteria

Not provided

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Exclusion Criteria

Not provided

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Normal, pathological cycle, infertility	Fertility treatment	healthy women PCOS Endometriosis hyperprolactinemia fertility treatment

Primary Outcome Measures

Name	Time	Method
Hormonal parameters	3 years	Development of a mathematical model of the menstrual cycle

Secondary Outcome Measures

Name	Time	Method
Dynamics of fertility treatment	2 years	Mathematical model to improve fertility treatments

Trial Locations

Locations (1)

University Hospital Zurich, Division of Reproductive Endocrinology; 🇨🇭 Zurich, ZH, Switzerland