NCT04586114Unknown不适用
Effect of Early Corticosteroid Therapy on Mortality in Patient With Acute Respiratory Distress Syndrome Secondary to Covid-19
Central Hospital, Nancy, France1 个研究点 分布在 1 个国家目标入组 200 人开始时间: 2020年3月1日最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Mortality in ICU
研究概览
简要总结
Study conducted on hospitalized patient in critical ill units in Nancy and Metz to evaluate if early corticosteroid treatment in first seven days after admission improve patients outcome in Acute Respiratory Distress Syndrome secondary to Covid-19 compared to later corticosteroid therapy or no treatment. Also comparison of acquired infection with or without corticosteroid treatment during hospitalisation.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ICU hospitalized with acute respiratory distress syndrome secondary to Sars-Cov-2 infection diagnosed by PCR test
- •Hospitalized from 01/03/2020 to 30/04/2020
排除标准
- •Mechanical ventilation more than 48 hours at admission
- •Transfert to another ICU during stay for bed management
- •Corticosteroid treatment at admission
研究组 & 干预措施
Early corticosteroid
Corticosteroid treatment within first seven days after ICU admission
干预措施: Corticosteroids and Derivatives (Drug)
Late corticosteroid
Corticosteroid treatment later than seventh day's after ICU admission
干预措施: Corticosteroids and Derivatives (Drug)
结局指标
主要结局
Mortality in ICU
时间窗: within ICU stay, on average 15 days
Mortality rates in ICU in each group
次要结局
- acquired infections incidence(28 days)
- antibiotics duration(28 days)
- Mortality d28(28 days)
- mechanical ventilation duration(28 days)
研究者
研究点 (1)
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