Stress and Sugar Synergy

Not Applicable

Completed

• Conditions: Insulin Resistance; Dyslipidemia; Metabolic Syndrome
• Interventions: Other: orange juice; Other: sucrose

• Registration Number: NCT02143011
• Lead Sponsor: University of California, Davis

Brief Summary

The main objectives of this study are to test the hypotheses that: 1) consumption of beverages sweetened with sucrose will increase risk factors for cardiovascular disease to a greater extent than a naturally-sweetened fruit juice such as orange juice, and 2) chronic psychological stress may augment the adverse metabolic effects of sugar intake. The study intervention consists of 2-week's consumption of 25% of energy as sugar provided either as a sucrose-sweetened beverage or naturally-sweetened orange juice.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-04
• Study First Submitted: 2014-05-16
• Study First Submitted QC: 2014-05-16
• Study First Posted: 2014-05-20
• Primary Completion: 2016-12
• Study Completion: 2016-12
• Status Verified: 2019-01
• Last Update Submitted: 2019-01-14
• Last Update Posted: 2019-01-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 23

Inclusion Criteria

• Body mass index between 28-35
• Self report of stable body weight during the past six months
• High stress participants: Perceived Stress Scores (PSS) ≥ 24, and the presence of a predefined chronically stressful event as assessed by the Telephone screening questions. (IDS scores are not an inclusion criteria in this group, merely a rule-out for the low stress participants).
• Low stress participants: PSS scores ≤ 8, Inventory for Depressive Symptom (IDS) scores ≤ 14, and the absence of any predefined chronically stressful events as assessed by the telephone screening questions.

Exclusion Criteria

• glucose intolerance
• Evidence of liver disorder
• Evidence of kidney disorder
• Evidence of thyroid disorder
• Systolic blood pressure consistently over 140mmHg or diastolic blood pressure over 90mmHg
• Triglycerides > 200mg/dl
• LDL-C > 130mg/dl
• Hemoglobin < 8.5 g/dl
• pregnant or lactating women
• Current, prior (within 12 months), or anticipated use of any hypolipidemic or anti-diabetic agents
• Use of Selective Serotonin Reuptake Inhibitors and anti-hypertensive medications
• Any other condition that, in the opinion of the investigators, would put subject at risk
• Strenuous exerciser
• surgery for weight loss
• Diet exclusions: food allergies, special dietary restrictions, habitual ingest of >2 alcoholic beverages/day

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
sugar beverage	sucrose	no sugar
sugar beverage	orange juice	no sugar
orange juice	orange juice	no sugar
orange juice	sucrose	no sugar

Primary Outcome Measures

Name	Time	Method
24-hour triglyceride area under the curve	Baseline and 2-week intervention	28 serial blood samples are collected over a 24 hour period.

Secondary Outcome Measures

Name	Time	Method
Markers of immune cell aging	Baseline and 2-week intervention

Trial Locations

Locations (1)

Clinical Research Center; 🇺🇸 Sacramento, California, United States