Autonomic response to exercise in individuals with intellectual disabilities

Completed

• Conditions: verstandelijke beperking; intellectual disability; mental handicap

• Registration Number: NL-OMON45683
• Lead Sponsor: Radboud Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 24

Inclusion Criteria

* Healthy males and females between 18 and 45 years of age
* Sedentary lifestyle (defined as being involved in less than 30 minutes of moderately-intense physical activity per day)
* For the ID group: Mild (IQ between 50-70) or moderate (IQ between 35-49) intellectual disability.

Exclusion Criteria

* Presence of any known genetic syndrome causing ID (e.g. Down syndrome)
* Severe or profound intellectual disability
* Motor impairments that would limit treadmill exercise
* History of cardiovascular disease, diabetes or any other metabolic disease that may affect the resting and exercise measures
* Inflammatory disease
* Asthma or other significant respiratory disorders
* Cancer in the last six months
* Any heart-rate-altering medications or any other medication that may alter metabolic responses
* Smoking
* Any contraindications to exercise, assessed with the revised Physical Activity Readiness Questionnaire
* Pregnancy
* Any other contra-indications to performing a maximal exercise test

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameter is the oxygen uptake during the maximal exercise test. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary study parameters are heart rate, heart rate variability and blood<br /><br>pressure during exercise and orthostasis.</p><br>