Tumor Immune Microenvironment Involvement in Colorectal Cancer Chemoresistance Mechanisms
- Conditions
- Colon TumorPrimary Tumor
- Registration Number
- NCT05038358
- Lead Sponsor
- University Hospital, Grenoble
- Brief Summary
Colorectal cancer is the third most common cancer worldwide and its progression-free survival is still low, around 10 months. Thirthy to 50% of patients do not respond to chemotherapy upon initiation of treatment, suggesting that early development of chemoresistance mechanisms remains a major challenge. In order to better characterize these mechanisms, the aim is to develop a model of tumoroids derived from patients with a colorectal tumors prior to any systemic anti cancer treatment. This project will both allow us to study the role of the immunological microenvironment in chemoresistance and identify new predictive markers of tumor response. It will then serve to develop innovative personalized medicine strategies by targeting the newly identified mechanisms. This study should in fine help to improve the cancer patient's care.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 60
- Male and female over 18 years old.
- Managed at the CHUGA for a colorectal adenocarcinoma
- With an indication for immediate surgical resection as part of the care.
- Patient naive from neo-adjuvant chemotherapy
- Patient did not object to the CRC-ORGA-2 study
- Patients protected by law (pregnant or breastfeeding women, minors, patients under guardianship or trusteeship, persons deprived of their liberty or hospitalized under duress).
- Patients with positive HIV, HBV, HCV serology.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Percentage of viable organoids for 60 days of culture maintenance. 60 days of culture maintenance.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University Hospital of Grenoble Alpes
🇫🇷Grenoble, France