Screening and Identification of Human Urate Transporter hURAT1 MicroRNA

Qian-wei Li0 sites80 target enrollmentNovember 2013

ConditionsUrinary Calculi

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Urinary Calculi
Sponsor: Qian-wei Li
Enrollment: 80
Primary Endpoint: micro-RNA
Last Updated: 12 years ago

Overview Investigators Eligibility Criteria Outcomes Similar Trials

Overview

Brief Summary

This study intends to use in patients with renal tissue and blood samples, screening and identification of renal tissue hURAT1 regulating the expression of micro-RNA, for further study of uric acid stone formation mechanism and the occurrence of clinical preventive uric acid stones provide new clues and new intervention targets.

Registry

clinicaltrials.gov

Start Date

November 2013

End Date

June 2015

Last Updated

12 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Qian-wei Li

Responsible Party

Sponsor Investigator

Principal Investigator

Qian-wei Li

Southwest Hospital, China

Eligibility Criteria

Inclusion Criteria

•A、B group were enrolled standards: ① aged 18-65 years old; ② comply with percutaneous nephrolithotomy lithotripsy indications for surgery; ③ ECT tips ipsilateral normal or mildly impaired renal function.
•Group C patients were enrolled standards: ① aged 18-65 years old; ② normal renal function, not associated with urinary calculi in patients; ③ cancer patients met radical nephrectomy indications for surgery; ④ emergency trauma patients suffering from kidney resection surgical indications.

Exclusion Criteria

•aged \<18 years or\> 65 years; ② neurological disease or cognitive dysfunction; ③ can not be corrected or uncorrected coagulopathy; ④ associated with diabetes, hypertension and other metabolic diseases; ⑤ accompanied by tuberculosis, hepatitis, HIV and other infectious diseases; ⑥ poor tolerance to anesthesia and surgery, such as: severe cardiopulmonary disease, coagulation disorders, etc.; ⑦ ultrasound, renal imaging examination revealed renal cortex was significantly thinner (renal cortical thickness \<1.5cm), structural variation; ⑧ with severe systemic or urinary tract infection; ⑨ ECT tips ipsilateral renal function is severely impaired or solitary kidney.