NCT07612046招募中不适用
Pilot Study of a Dedicated MR of the Pancreas: Improving Screening for Patients at High Risk for Pancreas Cancer
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 79
- 试验地点
- 7
研究概览
简要总结
The purpose of this study is to develop a dedicated MRI scan of the pancreas (MRP) to better detect pancreatic cancer in people who are at a high risk for pancreatic cancer.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Two first-degree relatives with pancreas cancer, one being a first-degree relative to the individual
- •Pathogenic mutation in APC, BRCA1, MLH1, MSH2, MSH6, PMS2, EPCAM, PALB2, or TP53 and a first/second-degree relative with pancreas cancer
- •Pathogenic mutation in CDKN2A/p16, STK11, PRSS1, SPINK1/PST1, CTRC, CPA1, ATM, or BRCA2
- •Meets surveillance age eligibility, which is typically age 50, or 10 years earlier than the youngest relative with pancreas cancer. For individuals with certain gene mutations, this can be earlier. All participants must be aged 21+
- •For this pilot MRP study, we will additionally apply the following Criteria:
- •Consents to follow-up contact
- •US residents
- •Completed MRI with MRCP with no actionable findings related to the pancreas (e.g. a pancreatic mass)
- •No metallic artifacts covering the pancreas on prior MRCP
- •Scheduled for endoscopic ultrasound
- •No new contraindications for MRI (e.g. new MR unsafe device)
- •No history of claustrophobia or use of anxiolytic on prior MRI
- •No history of abdominal surgery that may affect interpretation of either EUS or MR
- •No medical conditions that confers increased and/or unacceptable risk for anesthesia
- •We will recruit surveillance participants who had at least one prior MRCP in the last 3 years. They must also undergo a same-day EUS procedure as part of their surveillance. Nearly all active cohort participants have had at least one recent MRCP and, on average, our Registry gastroenterologist Dr. Rolston performs EUS in ~260 surveillance participants per year. Accordingly, it is highly feasible to recruit more than 79 participants in the grant period, and recruitment is constrained by budget.
- •Documentation of Disease
- •o No pathologic confirmation of disease is necessary
- •Definition of Disease N/A
- •Required Organ Function N/A
排除标准
- 未提供
研究组 & 干预措施
Participants at high risk for pancreas ductal adenocarcinoma
Participants will be high-risk individuals enrolled in the Memorial Sloan Kettering Pancreatic Tumor Registry
干预措施: MRI (Diagnostic Test)
Participants at high risk for pancreas ductal adenocarcinoma
Participants will be high-risk individuals enrolled in the Memorial Sloan Kettering Pancreatic Tumor Registry
干预措施: Endoscopic ultrasound (Diagnostic Test)
研究者
研究点 (7)
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