Treatment for Depressed, Obese Individuals at Risk for Cardiovascular Disease (CVD)

Not Applicable

Completed

• Conditions: Major Depressive Disorder; Dysthymic Disorder; Cardiovascular Disease; Obesity

• Registration Number: NCT01692574
• Lead Sponsor: University of Pennsylvania

Brief Summary

To determine whether individuals who suffer from depression and obesity are able to lose weight and show improvements in mood and cardiovascular disease risk factors following 20 weeks of a combined treatment of cognitive-behavior therapy for depression and behavior modification for weight loss. Participants will be assigned to one of three treatments: 1) cognitive-behavior therapy for the treatment of depression combined with an alternative approach to weight loss, 2) a weight loss intervention combined with a depression support and education , or 3) cognitive-behavioral therapy for depression combined with a weight loss intervention.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-08
• Study First Submitted: 2012-09-20
• Study First Submitted QC: 2012-09-20
• Study First Posted: 2012-09-25
• Primary Completion: 2015-11
• Study Completion: 2015-11
• Status Verified: 2016-08
• Last Update Submitted: 2016-08-18
• Last Update Posted: 2016-08-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 76

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Primary Outcome Measures

Name	Time	Method
Weight loss	Baseline to 20 weeks of treatment, follow-up at week 46	To determine whether depressed, obese individuals who receive the combined treatment of cognitive-behavior therapy for depression and behavior modification for weight loss are able to lose 5% of their initial weight at the end of 20 weeks of treatment.

Secondary Outcome Measures

Name	Time	Method
Changes in metabolic cardiovascular disease risk factors and inflammatory markers	Baseline to 20 weeks of treatment, follow up at week 46

Trial Locations

Locations (1)

University of Pennsylvania: Center for Weight and Eating Disorders; 🇺🇸 Philadelphia, Pennsylvania, United States