Clinicopathological study on the pulmonary vasculopathy and cardiac dysfunction in pulmonary hypertensio
Not Applicable
- Conditions
- pulmonary hypertension, interstitial lung disease, chronic obstructive pulmonary disease
- Registration Number
- JPRN-UMIN000047417
- Lead Sponsor
- Hokkaido University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up continuing
- Sex
- All
- Target Recruitment
- 17
Inclusion Criteria
Not provided
Exclusion Criteria
Those who are judged by the principal investigator to be inappropriate as research subjects
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Area ratio of media and intima of pulmonary muscular arteries
- Secondary Outcome Measures
Name Time Method 1. Luminal stenosis rate of pulmonary muscular arteries 2. Distribution density, wall thickening, and stenosis or dilation of pulmonary veins and lymph vessels; the presence and the degree, if present, of capillary lesions 3. Relationship between the degree of pulmonary vascular lesions and background lung lesions (emphysema, fibrosis, etc.) 4. The degree, if present, of pathological changes such as myocardial hypertrophy and fibrosis 5. Histological analysis on the target protein of pulmonary vasodilators in pulmonary blood vessels and myocardium 6. Relationship between the morphological findings and clinical course including the treatment response