Psychological and Biological Responses to Choral Singing in Mentally Ill, Socially Underprivileged and Privileged Healthy Children and Adolescents: An Open, Single-Arm, Controlled Study
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 135
- 试验地点
- 3
- 主要终点
- Change Short-Term Immune Function from pre- to post singing session over six months
研究概览
简要总结
Interventional, three-armed, open, monocentric, medium-term follow-up, pre-test-post-test design, controlled, parallel group study to investigate the effects of a group singing intervention on neuroendocrine (hair cortisol, salivary cortisol, salivary alpha amylase), immune (salivary immunoglobulin A/s-IgA), and psychological (psychological stress, mood, social contacts, emotional and social competence, self-esteem, and quality of life) responses in mentally ill and healthy children and adolescents (N=135, age range 10 -18).
Additionally, the child and adolescent psychiatry group (age range 13-18) takes part in three hour creative workshops every two weeks.
详细描述
Background: Biopsychological responses to music-related activities (MRA) were examined in various naturalistic settings in adults. Group singing in particular seems to be associated with positive biopsychological outcomes. There is also an emerging view that MRA may play an important role for youth with mental disorders. However, longitudinal research on biopsychological responses to MRA in different clinical and healthy populations among children and adolescents is lacking.
Method: Children and adolescents (age range 10-18) under psychiatric treatment at the Department of Child and Adolescents Psychiatry in Salzburg (n=45), healthy children and adolescents from a school in Salzburg (n=45), and members from the Vienna Boys Choir (n=45) in Austria will be recruited to take part in the study. Subjective measures (mood, stress experience) will be taken pre- and post singing sessions once a week throughout six months. Additionally, salivary biomarkers (cortisol, alpha amylase and IgA), social contacts, and quality of life are assessed. Emotional competence, social competence, self-esteem, and chronic stress levels are measured at the beginning, after three months, at the end, and in a follow-up of the study.
The group of child and adolescent psychiatry taking part in the creative workshops will be additionally assessed via questionnaires regarding emotional regulation, self-esteem, and art experience before and after every workshop. Furthermore, some individuals of the child and adolescent psychiatry group will undergo fMRI evaluation of the brain before and after completion of all creative interventions.
Conclusion: Singing and other creative activities are suggested to benefit mental and physical health in children and adolescents. However, despite the current knowledge, the researchers must better understand the biopsychological mechanisms underlying choral singing in order to determine its full potential, particularly for vulnerable populations. This is the first study to investigate this issue in this population.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 10 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •(Clinical N):
- •Written consent to study participation;
- •Gender: male, female, different;
- •Age: children and adolescents aged ≥ 10 and ≤ 18 years;
- •Diagnosis of a psychiatric disorder according to ICD-10;
- •Patients are admitted regardless of medication status and are allowed to the medication will continue to be used during the study;
- •Additional therapies and medication are recorded and are not an exclusion criterion;
- •Musical skills or a certain musical background are not required
- •Inclusion Criteria (Healthy N):
- •Written consent to study participation;
- •Gender: male, female, different;
- •Age: children and adolescents aged ≥ 10 and ≤ 18 years;
- •Musical skills or a certain musical background are not required
排除标准
- •(Clinical N):
- •Age: children and adolescents aged <10 years and > 18 years;
- •Criteria that prevent an application: hearing loss, states of confusion, inability to verbalize;
- •Patients with acute externalizing behavior or self-harm/suicidality;
- •Existing alcohol addiction or abuse of illegal drugs;
- •Exclusion Criteria (Healthy N):
- •Age: children and adolescents aged <10 years and > 18 years
- •Criteria that prevent an application: hearing loss, states of confusion, inability to verbalize
研究组 & 干预措施
SBGmentdis
Children and adolescents with mental disorders at the Department of Child and Adolescents Psychiatry in Salzburg, Austria
干预措施: "Amateur" Group Singing (Behavioral)
SBGhealthy
Healthy children and adolescents from schools in Salzburg, Austria
干预措施: "Amateur" Group Singing (Behavioral)
VIEhealthy
Members from the Vienna Boys Choir, Austria
干预措施: "Professional" Group Singing (Behavioral)
结局指标
主要结局
Change Short-Term Immune Function from pre- to post singing session over six months
时间窗: every two weeks pre- and post singing sessions for six months
Biological Marker: Salivary Immunoglobulin A
Change Short-Term Neuroendocrine Stress (Hypothalamic-Pituitary-Adrenal Axis) from pre- to post singing session over six months
时间窗: every two weeks pre- and post singing sessions for six months
Biological Stress Marker: Salivary Cortisol
Change from Baseline Chronic Neuroendocrine Stress (Hypothalamic-Pituitary-Adrenal Axis) at three and six months
时间窗: at the beginning of the study, after three months, at the end of the study after six months, at a follow-up after three months, at a follow up after six months
Biological Stress Marker: Hair Cortisol
Change Short-Term Neuroendocrine Stress (Autonomic Nervous System) from pre- to post singing session over six months
时间窗: every two weeks pre- and post singing sessions for six months
Salivary Alpha-Amylase
次要结局
- Life Quality(once a month for six months)
- Mood(every week pre- and post singing sessions for six months)
- Performance Anxiety(once at the beginning of the study, once after 6 months)
- Emotional Skills(at the beginning of the study, after three months, at the end of the study after six months, at a follow-up after three months, at a follow up after six months)
- Self-Esteem(at the beginning of the study, after three months, at the end of the study after six months, at a follow-up after three months, at a follow up after six months)
- Evaluation of the choir session(every week post singing sessions for six months)
- Stress Perception(every week pre- and post singing sessions for six months)
- Psychological Stability (children view)(at the beginning of the study, after three months, at the end of the study after six months, at a follow-up after three months, at a follow up after six months)
- Emotional Control(at the beginning of the study, after three months, at the end of the study after six months, at a follow-up after three months, at a follow up after six months)
- Specific personality and character traits such as curiosity, reward dependency, cooperativity, and self-steering ability(At the beginning of creative workshops, and at a follow-up after three months in the group of children and adolescents with psychiatric disorders)
- Psychological Stress(at the beginning of the study, after three months, at the end of the study after six months, at a follow-up after three months, at a follow up after six months)
- Social Skills(at the beginning of the study, after three months, at the end of the study after six months, at a follow-up after three months, at a follow up after six months)
- Chronical Stress(at the beginning of the study, after three months, at the end of the study after six months, at a follow-up after three months, at a follow up after six months)
- Psychological Stability (parents view)(at the beginning of the study, after three months, at the end of the study after six months, at a follow-up after three months, at a follow up after six months)
- Prosocial Behavior(every two weeks post singing sessions for six months)
- Current emotional state(Pre and post every creative workshop in the group of children and adolescents with psychiatric disorders)
研究者
Katarzyna Grebosz-Haring
Senior Scientist, Principal Investigator
University of Salzburg