Identifying Predictors of Response in 12 Weeks of Treatment With Antipsychotics Using a Treatment Algorithm for Schizophrenia
试验速览
- 阶段
- 4 期
- 入组人数
- 126
- 试验地点
- 1
- 主要终点
- % responders to first generation antipsychotics vs. % responders to second generation antipsychotics
研究概览
简要总结
The objective of this study is to evaluate predictors of response to antipsychotic medication in subjects with schizophrenia. The investigators will evaluate psychopathology,brain MRI, genetics and neuropsychological profile. Two groups of treatment will be compared: first generation antipsychotics vs. second generation antipsychotics. Participants will be randomized to one of the groups. Trial duration: 12 weeks.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Schizophrenia or schizoaffective disorder
- •Age: 18-45 years olde
- •Less than 10 years of diagnosis
- •Acute exacerbation of psychotic symptoms
排除标准
- •Use of clozapine
- •Clinical unstable disease
- •Delirium and cognitive disorders
研究组 & 干预措施
First generation antipsychotic
Subjects randomized to this arm will receive treatment with haloperidol or chlorpromazine.
干预措施: Antipsychotics (Drug)
Second generation antipsychotics
Subjects randomized to this arm will receive treatment with a second-generation antipsychotic: risperidone or olanzapine or aripiprazole or quetiapine or ziprasidone
干预措施: Antipsychotics (Drug)
结局指标
主要结局
% responders to first generation antipsychotics vs. % responders to second generation antipsychotics
时间窗: 8-12 weeks
次要结局
- % of treatment abandon and respective causes(8-12 weeks)