The Effect of Humidification on Mucus Rheology
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 18
- 试验地点
- 1
- 主要终点
- Sputum Collection
研究概览
简要总结
In this study the investigators will collect mucus from mechanical ventilated patients and patients with COPD to study the effect of temperature and humidity, on the biophysical properties of the airway mucus. It is hypothesised that changes in inspired gas temperature and humidity (over time) may affect the biophysical properties of the airway mucus and reduce the airway's ability to clear mucus, resulting in deleterious clinical affects.
详细描述
Expectorated sputum samples are collected and used to measure the biophysical properties of mucus secretions. The samples are later exposed to different temperatures and humidity levels during bench experiments.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 40 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Any Subject Mechanically Ventilated and producing sputum.
- •Inclusion Criteria:
- •40 to 90 years of age suffering from COPD
- •History of mucus production
排除标准
- 未提供
结局指标
主要结局
Sputum Collection
时间窗: 10 minutes
Sputum is collected during pulmonary function test (PFT) to later measure the biophysical properties of sputum.
次要结局
未报告次要终点