The Effect of Humidification on Mucus Rheology

Completed

• Conditions: Chronic Obstructive Pulmonary Disease(COPD)

• Registration Number: NCT01661374
• Lead Sponsor: Virginia Commonwealth University

Brief Summary

In this study the investigators will collect mucus from mechanical ventilated patients and patients with COPD to study the effect of temperature and humidity, on the biophysical properties of the airway mucus. It is hypothesised that changes in inspired gas temperature and humidity (over time) may affect the biophysical properties of the airway mucus and reduce the airway's ability to clear mucus, resulting in deleterious clinical affects.

Detailed Description

Expectorated sputum samples are collected and used to measure the biophysical properties of mucus secretions. The samples are later exposed to different temperatures and humidity levels during bench experiments.

Study Timeline

• Study Start: 2012-07
• Study First Submitted: 2012-08-06
• Study First Submitted QC: 2012-08-08
• Study First Posted: 2012-08-09
• Primary Completion: 2014-04
• Study Completion: 2014-04
• Status Verified: 2014-12
• Last Update Submitted: 2014-12-09
• Last Update Posted: 2014-12-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 18

Inclusion Criteria

Any Subject Mechanically Ventilated and producing sputum.

Exclusion

• None

COPD Group

Inclusion Criteria:

• 40 to 90 years of age suffering from COPD
• History of mucus production

Exclusion Criteria

• None

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Sputum Collection	10 minutes	Sputum is collected during pulmonary function test (PFT) to later measure the biophysical properties of sputum.

Trial Locations

Locations (1)

Virginia Commonwealth University; 🇺🇸 Richmond, Virginia, United States