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临床试验/NCT07488182
NCT07488182尚未招募不适用

The Value of Preoperative Carotid Doppler Ultrasonography Parameters in Predicting Post-Induction Hypotension in Patients Undergoing Elective Non-Cardiac Surgery

Necmettin Erbakan University1 个研究点 分布在 1 个国家目标入组 110 人开始时间: 2026年9月1日最近更新:

试验速览

阶段
不适用
状态
尚未招募
入组人数
110
试验地点
1
主要终点
Post-induction hypotension

研究概览

简要总结

This prospective observational study aims to evaluate the predictive value of preoperative carotid Doppler ultrasound parameters, including carotid velocity-time integral (carotid VTI) and corrected carotid flow time (ccFT), for post-induction hypotension in adult patients undergoing elective non-cardiac surgery under general anesthesia. Hemodynamic instability during anesthesia induction is a common and clinically important problem associated with adverse perioperative outcomes. Carotid Doppler ultrasonography provides a rapid and non-invasive method for assessing hemodynamic status at the bedside. In this study, carotid Doppler measurements will be performed in the preoperative period and their association with post-induction hypotension will be analyzed. The results of this study may help identify patients at risk for hypotension and improve perioperative hemodynamic management.

详细描述

Post-induction hypotension (PIH) is a common hemodynamic complication during the induction of general anesthesia and is associated with increased risk of perioperative morbidity and mortality. Identifying patients at risk of developing hypotension before anesthesia induction may allow anesthesiologists to implement preventive strategies and optimize perioperative hemodynamic management.

Traditional static hemodynamic parameters are often insufficient to accurately assess intravascular volume status and cardiovascular reserve. Doppler ultrasound-based measurements have emerged as useful non-invasive tools for evaluating cardiovascular dynamics. Carotid Doppler ultrasonography, in particular, allows rapid bedside assessment of hemodynamic parameters such as carotid velocity-time integral (carotid VTI) and corrected carotid flow time (ccFT), which may reflect changes in stroke volume and preload responsiveness.

This prospective observational study aims to evaluate the ability of preoperative carotid Doppler parameters, including carotid VTI and corrected carotid flow time (ccFT), to predict the development of post-induction hypotension in adult patients undergoing elective non-cardiac surgery under general anesthesia. Carotid Doppler measurements will be performed during the preoperative period, and anesthetic induction will be conducted in accordance with the study protocol under standard monitoring conditions. Hemodynamic parameters will be recorded during the induction period, and the occurrence of post-induction hypotension will be documented.

The primary objective of this study is to determine the predictive performance of carotid VTI and corrected carotid flow time for post-induction hypotension. Secondary analyses will explore the relationship between Doppler-derived hemodynamic parameters and perioperative hemodynamic changes. The findings of this study may contribute to improving perioperative risk stratification and guiding individualized hemodynamic management strategies.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 65 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Adult patients aged 18-65 years
  • American Society of Anesthesiologists (ASA) physical status I-II
  • Scheduled for elective non-cardiac surgery under general anesthesia
  • Planned endotracheal intubation
  • Ability to provide written informed consent

排除标准

  • Refusal to participate in the study
  • Planned emergency surgery
  • Planned cardiac surgery
  • Presence of carotid artery stenosis greater than 50%
  • Moderate to severe valvular heart disease
  • Presence of atrial fibrillation or significant arrhythmia
  • Advanced heart failure
  • Preoperative hypotension or hemodynamic instability
  • Inability to obtain reliable ultrasonographic measurements

结局指标

主要结局

Post-induction hypotension

时间窗: From anesthesia induction until 10 minutes after tracheal intubation or until the start of surgery, whichever occurs first.

Occurrence of post-induction hypotension after anesthesia induction, defined as either a decrease in mean arterial pressure (MAP) of ≥30% from baseline or a MAP \<65 mmHg sustained for at least 1 minute.

次要结局

  • Predictive performance of carotid Doppler parameters(From the initiation of anesthetic induction until 10 minutes after tracheal intubation or until surgical incision, whichever occurs first.)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

ŞULE ARICAN

Assoc.Prof.MD

Necmettin Erbakan University

研究点 (1)

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